S-Space College of Medicine/School of Medicine (의과대학/대학원) Otorhinolaryngology (이비인후과학전공) Journal Papers (저널논문_이비인후과학전공)
Purinergic signaling in the inner ear
- Lee, Jun Ho; Marcus, Daniel C
- Issue Date
- Hear Res. 2008 ;235(1-2):1-7.
- Acoustic Stimulation/adverse effects; Animals; Auditory Pathways/*metabolism; Ear, Inner/injuries/*metabolism; Endolymph/metabolism; Epithelial Cells/metabolism; Humans; Hydrolysis; Mechanotransduction, Cellular; Noise/adverse effects; Purine Nucleotides/*metabolism; Receptors, Purinergic/*metabolism; Receptors, Purinergic P1/metabolism; Receptors, Purinergic P2/metabolism; *Signal Transduction
- Epithelial cells of the inner ear coordinate their ion transport activity through a number of mechanisms. One important mechanism is the autocrine and paracrine signaling among neighboring cells in the ear via nucleotides, such as adenosine, ATP and UTP. This review summarizes observations on the release, detection and degradation of nucleotides by epithelial cells of the inner ear. Purinergic signaling is thought to be important for endolymph ion homeostasis and for protection from acoustic over-stimulation.
- 0378-5955 (Print)
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