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Purinergic signaling in the inner ear

Cited 23 time in Web of Science Cited 27 time in Scopus
Authors
Lee, Jun Ho; Marcus, Daniel C
Issue Date
2007-11-06
Publisher
Elsevier
Citation
Hear Res. 2008 ;235(1-2):1-7.
Keywords
Acoustic Stimulation/adverse effectsAnimalsAuditory Pathways/*metabolismEar, Inner/injuries/*metabolismEndolymph/metabolismEpithelial Cells/metabolismHumansHydrolysisMechanotransduction, CellularNoise/adverse effectsPurine Nucleotides/*metabolismReceptors, Purinergic/*metabolismReceptors, Purinergic P1/metabolismReceptors, Purinergic P2/metabolism*Signal Transduction
Abstract
Epithelial cells of the inner ear coordinate their ion transport activity through a number of mechanisms. One important mechanism is the autocrine and paracrine signaling among neighboring cells in the ear via nucleotides, such as adenosine, ATP and UTP. This review summarizes observations on the release, detection and degradation of nucleotides by epithelial cells of the inner ear. Purinergic signaling is thought to be important for endolymph ion homeostasis and for protection from acoustic over-stimulation.
ISSN
0378-5955 (Print)
Language
English
URI
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17980525

http://hdl.handle.net/10371/63068
DOI
https://doi.org/10.1016/j.heares.2007.09.006
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Appears in Collections:
College of Medicine/School of Medicine (의과대학/대학원)Otorhinolaryngology (이비인후과학전공)Journal Papers (저널논문_이비인후과학전공)
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