The effects of daily irradiation with polychromatic visible polarized light on human lymphocyte populations

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Lim, Jeong H; Lee, Jongmin; Lee, In S; Kim, Youn J; Song, Eun Y; Choi, Young S; Yun, Yeo Min

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Mary Ann Liebert
Photomed Laser Surg. 2008 Aug;26(4):361-6.
AdultAntigens, CD3Antigens, CD4Antigens, Differentiation, T-Lymphocyte/*immunologyCD4-Positive T-Lymphocytes/immunologyDouble-Blind MethodFemaleHumansImmunity, Cellular/immunology/radiation effectsLightLymphocyte CountLymphocyte Subsets/*immunologyLymphocytes/*immunologyMaleMiddle AgedPhototherapy
OBJECTIVE: The goal of this randomized, placebo controlled, double-blind study was to investigate the effects of transcutaneous irradiation with polychromatic visible polarized light (540-780 nm; 68% polarization; power density 3.0 E-10 W/cm(2)) on a subset population of human lymphocytes using flow cytometry. BACKGROUND DATA: The biomodulation and therapeutic effects of visible light of different wavelengths are well known, but the immunological effects of polychromatic visible polarized light have not been investigated sufficiently. METHODS: Before and after 28 consecutive days of irradiation, blood samples were collected from the subjects and the population count of the lymphocyte subset was measured. RESULTS: The absolute count of total lymphocytes, CD3(+) lymphocytes, and CD3(+)CD4(+) lymphocytes increased by 7% (p = 0.023), 9% (p = 0.058), and 13% (p = 0.021), respectively. Yet the absolute count of WBCs, CD3(+)CD8(+), CD19(+), and CD16(+)56(+) lymphocytes did not change significantly. CONCLUSION: The application of polychromatic visible polarized light with the aforementioned features increases the CD3(+)CD4(+) lymphocyte population. It is suggested that this regimen may be useful for the promotion of natural defenses in cell-mediated immunity.
1557-8550 (Electronic)
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College of Medicine/School of Medicine (의과대학/대학원)Laboratory Medicine (검사의학전공)Journal Papers (저널논문_검사의학전공)
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