S-Space College of Medicine/School of Medicine (의과대학/대학원) Psychiatry (정신과학전공) Journal Papers (저널논문_정신과학전공)
Structural abnormalities of the right inferior colliculus in schizophrenia
Cited 17 time in Web of Science Cited 16 time in Scopus
- Issue Date
- Psychiatry Res. 2008 30;164(2):160-5.
- Adult ; Attention ; Auditory Perceptual Disorders/epidemiology ; Cognition Disorders/diagnosis/epidemiology ; Diagnostic and Statistical Manual of Mental Disorders ; Female ; Functional Laterality/physiology ; Humans ; Inferior Colliculi/*abnormalities ; Male ; Neuropsychological Tests ; Saccades/physiology ; Schizophrenia/*diagnosis/epidemiology
- Although structural and functional neuroimaging studies of schizophrenia have suggested that impaired connectivity in the extensive network of cortical and subcortical areas is involved in its pathophysiology, there were no studies have investigated the structural integrity of the lower sensory brain areas including the inferior (IC) and the superior (SC) colliculus. The IC plays an important role in mediating auditory gating processes and inhibitory neural transmission, while the SC is a key structure in a distributed network mediating saccadic eye movements and shifts of attention, both of which have been linked to the pathophysiology of schizophrenia. We compared the morphologies of the IC and SC, which are involved in the early stage processing of visual and auditory stimuli, in patients with schizophrenia (N=28) and healthy controls (N=34) using high-resolution magnetic resonance imaging. Subjects with schizophrenia had a significantly smaller right IC, compared with controls. The reduced IC volume suggests that a structural abnormality of the IC in patients with schizophrenia may be involved in the auditory cognitive dysfunction of schizophrenia.
- 0165-1781 (Print)
- Files in This Item: There are no files associated with this item.
- Appears in Collections:
- College of Medicine/School of Medicine (의과대학/대학원)Psychiatry (정신과학전공)Journal Papers (저널논문_정신과학전공)
Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.