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Structural abnormalities of the right inferior colliculus in schizophrenia

Cited 17 time in Web of Science Cited 16 time in Scopus
Authors

Kang, Do-Hyung; Kwon, Ki Won; Gu, Bon-Mi; Choi, Jung-Seok; Jang, Joon Hwan; Kwon, Jun Soo

Issue Date
2008-10-22
Publisher
Elsevier
Citation
Psychiatry Res. 2008 30;164(2):160-5.
Keywords
AdultAttentionAuditory Perceptual Disorders/epidemiologyCognition Disorders/diagnosis/epidemiologyDiagnostic and Statistical Manual of Mental DisordersFemaleFunctional Laterality/physiologyHumansInferior Colliculi/*abnormalitiesMaleNeuropsychological TestsSaccades/physiologySchizophrenia/*diagnosis/epidemiology
Abstract
Although structural and functional neuroimaging studies of schizophrenia have suggested that impaired connectivity in the extensive network of cortical and subcortical areas is involved in its pathophysiology, there were no studies have investigated the structural integrity of the lower sensory brain areas including the inferior (IC) and the superior (SC) colliculus. The IC plays an important role in mediating auditory gating processes and inhibitory neural transmission, while the SC is a key structure in a distributed network mediating saccadic eye movements and shifts of attention, both of which have been linked to the pathophysiology of schizophrenia. We compared the morphologies of the IC and SC, which are involved in the early stage processing of visual and auditory stimuli, in patients with schizophrenia (N=28) and healthy controls (N=34) using high-resolution magnetic resonance imaging. Subjects with schizophrenia had a significantly smaller right IC, compared with controls. The reduced IC volume suggests that a structural abnormality of the IC in patients with schizophrenia may be involved in the auditory cognitive dysfunction of schizophrenia.
ISSN
0165-1781 (Print)
Language
English
URI
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=18930380

https://hdl.handle.net/10371/63319
DOI
https://doi.org/10.1016/j.pscychresns.2007.12.023
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