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Gray matter deficits in young adults with narcolepsy

Cited 23 time in Web of Science Cited 24 time in Scopus
Authors
Kim, SJ; Lyoo, IK; Lee, YS; Lee, J-Y; Yoon, SJ; Kim, JE; Kim, JH; Hong, SJ; Jeong, D-U
Issue Date
2008-07-16
Publisher
Wiley-Blackwell
Citation
Acta Neurol Scand. 2009 ;119(1):61-7.
Keywords
AdultAge of OnsetChildChild, PreschoolFemaleFunctional LateralityHumansHypothalamus/abnormalitiesKoreaMaleNarcolepsy/*pathology/physiopathologyPeriaqueductal Gray/anatomy & histology/*pathologyQuestionnairesReference ValuesSleep/physiologySleep Apnea, Obstructive/*pathology/physiopathologySleep, REM/physiologyYoung Adult
Abstract
OBJECTIVES: The aim of this study was to investigate gray matter volume changes in narcolepsy. MATERIALS AND METHODS: An optimized voxel-based morphometry was conducted for 17 young adults with a sole diagnosis of human leukocyte antigen DQB(1) 0602 positive narcolepsy with cataplexy (26.6 +/- 5.2 years old) and 17 comparison subjects (24.6 +/- 4.9 years old) using 3 Tesla scanner. Gray matter volumes in the bilateral hypothalamic voxel of interests (VOI) were also calculated. RESULTS: Compared with the comparison subjects, narcoleptic patients had gray matter volume decrease in the right hypothalamus and other regions including subcortical, prefrontal, limbic and occipital areas. Narcoleptic patients also had lower gray matter volume on predefined VOI at the bilateral hypothalamus, which correlated with the Ullanlinna Narcolepsy Scale score. CONCLUSIONS: Current findings suggest that narcoleptic patients have structural abnormalities in hypothalamus, which might be related to the clinical manifestation of narcolepsy with cataplexy.
ISSN
1600-0404 (Electronic)
0001-6314 (Print)
Language
English
URI
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=18624787

https://hdl.handle.net/10371/63325
DOI
https://doi.org/10.1111/j.1600-0404.2008.01063.x
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College of Medicine/School of Medicine (의과대학/대학원)Psychiatry (정신과학전공)Journal Papers (저널논문_정신과학전공)
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