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HBsAg+ and HBsAg- Chronic Active Hepatitis, Liver Cirrhosis and Hepatocellular Carcinoma in Korea:Prevalence and Difference in Age Distribution

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Authors
Kim, Chung Yong; Lee, Hyo-Suk; Yim, Kyong Wook
Issue Date
1992-06
Publisher
Seoul National University College of Medicine
Citation
Seoul J Med, Vol.33 No.2, pp. 127-131
Keywords
Hepatitis B viral markersHepatitis B surface antigenChronic active hepatitisLiver cirrhosisHepatocellular carcinomaKorea
Abstract
Korea is one of the endemic areas of hepatitis B virus infection. In clinical
practice, we have suspected that HBsAg+ patients with chronic liver disease (CLD) are
younger than HBsAg - patient. In order to determine the prevalence of HBV infection
more clearly in patients with CLD and to investigate the difference in age-specific distribution
between HBsAg+ and HBsAg- patients, we consecutively enrolled 3185 patients
with chronic active hepatitis (CAl-I), 1919 patients with liver cirrhosis (LC) and 628
patients with hepatocellular carcinoma (HCC) who were diagnosed in the liver unit at
Seoul National University Hospital from 1973 to 1991. HBsAg was positive in 61.4%,
67.8% and 68.9% of patients with CAH, LC and HCC, respectively. In comparison,
anti-HBs was positive only in 16.4%, 14.4% and 11.6% of patients with CAH, LC and
HCC, respectively. Among HBsAg- patients, patients with isolated antibody to HBc
were most common; 15.6%, 13.9% and 15.4% in CAH, LC and HCC, respectively.
Almost all of the patients with CAH, LC and HCC (93.4%, 96.1% and 95.9%, respectively)
were positive for any of HBV serological markers. The mean ages of HBsAg+ and
HBsAg- patients with CAH, LC and HCC were 38.0 and 45.8, 45.6 and 51.2, and 49.5
and 55.5 years, respectively; the differences between HBsAg+ and HBsAg- patients
were statistically significant in each CLD (p(0.01). When HBsAg- groups were
subdivided into 4 smaller subgroups according to HBV antibody profiles, such
differences were not demonstrated among 4 HBsAg- subgroups. Intervals in years between
CAH and LC and between LC and HCC were not different according to HBsAg
status in the serum. We concluded that the prevalence of present and past HBV infection
in patients with CLD in Korea was extremely high, and that HBsAg+ patients developed
CLD at a younger age than HBsAg- patients, the reason for which remains to
be established.
ISSN
0582-6802
Language
English
URI
http://hdl.handle.net/10371/6348
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College of Medicine/School of Medicine (의과대학/대학원)Dept. of Medicine (의학과)The Seoul Journal of MedicineThe Seoul Journal of Medicine Vol. 33 No.2 (1992)
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