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A prospective consecutive study of instrumented posterolateral lumbar fusion using synthetic hydroxyapatite (Bongros-HA) as a bone graft extender

Cited 31 time in Web of Science Cited 35 time in Scopus
Authors
Lee, Jae Hyup; Hwang, Chang-Ju; Song, Byung-Wook; Koo, Ki-Hyung; Chang, Bong-Soon; Lee, Choon-Ki
Issue Date
2008-07-11
Publisher
Wiley-Blackwell
Citation
J Biomed Mater Res A. 2009 S90(3):804-10.
Keywords
AdultAgedAged, 80 and overBone Transplantation/*methodsDurapatite/*therapeutic useFemaleHumansKineticsLumbosacral Region/*surgeryMaleMiddle AgedProspective StudiesSpinal Fusion/*methodsTransplantation, AutologousTreatment Outcome
Abstract
A prospective, single institution, clinical case-matched, radiographic study was undertaken. Thirty-two patients underwent posterior lumbar interbody fusion with cages containing laminectomized bone chips and posterolateral lumbar fusion with pedicle screws. Autogenous bone graft (3 mL) plus 3 mL of hydroxyapatite was placed in one side of a posterolateral gutter, and 6 mL of autogenous iliac bone graft was placed on the other side. Bony union, volumes of fusion mass, and bone absorption rates were postoperatively evaluated using simple radiographs and 3D-CT scans. Average postoperative Lenke scores at 3 and 6 months in the hydroxyapatite group were statistically higher than in the autograft group, but at 12 months no difference was found between the hydroxyapatite and autograft groups in terms of fusion rate. Complete fusion rates by 3D-CT were 86.7% in the hydroxyapatite group and 88.9% in the autograft group, which are not significantly different. Volumes of fusion mass and bone absorption rates at 12 months were 2.35 mL in the hydroxyapatite group and 1.31 mL in the autograft group. The mean fusion mass volume was greater in the hydroxyapatite group than in the autograft group. Lumbar posterolateral fusion using a mixture of hydroxyapatite artificial bone and autogenous bone graft showed good bony union similar to that shown with autogenous bone only. This study suggests that hydroxyapatite bone chips could be used usefully as a bone-graft extender in short-segment posterolateral spinal fusion.
ISSN
1552-4965 (Electronic)
Language
English
URI
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=18615472

https://hdl.handle.net/10371/63622
DOI
https://doi.org/10.1002/jbm.a.32113
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College of Medicine/School of Medicine (의과대학/대학원)Orthopedic Surgery (정형외과학전공)Journal Papers (저널논문_정형외과학전공)
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