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Human originated bacteria, Lactobacillus rhamnosus PL60, produce conjugated linoleic acid and show anti-obesity effects in diet-induced obese mice

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dc.contributor.authorLee, Hui-Young-
dc.contributor.authorPark, Jong-Hwan-
dc.contributor.authorSeok, Seung-Hyeok-
dc.contributor.authorBaek, Min-Won-
dc.contributor.authorKim, Dong-Jae-
dc.contributor.authorLee, Ki-Eun-
dc.contributor.authorPaek, Kyung-Soo-
dc.contributor.authorLee, Yeonhee-
dc.contributor.authorPark, Jae Hak-
dc.date.accessioned2009-08-07T02:49:13Z-
dc.date.available2009-08-07T02:49:13Z-
dc.date.issued2006-05-20-
dc.identifier.citationBiochim Biophys Acta. 1761 (2006) 736–744en
dc.identifier.issn1388-1981-
dc.identifier.urihttps://hdl.handle.net/10371/6474-
dc.description.abstractMany previous studies have reported that conjugated linoleic acid could be produced by starter culture bacteria, but the effects of the bacteria were not investigated. Moreover, there was no evidence of the conjugated linoleic acid-producing bacteria having potential health or nutritional effects related to conjugated linoleic acid, including reducing body fat. Here, we investigated the anti-obesity effect of Lactobacillus rhamnosus PL60, a human originated bacterium that produces t10, c12-conjugated linoleic acid, on diet-induced obese mice. After 8 weeks of feeding, L. rhamnosus PL60 reduced body weight without reducing energy intake, and caused a significant, specific reduction of white adipose tissue (epididymal and perirenal). Although the size of epididymal adipocytes was not reduced by L. rhamnosus PL60, apoptotic signals and UCP-2 mRNA levels increased in adipose tissue. Liver steatosis, a well known side effect of CLA, was not observed by L. rhamnosus PL60 treatment; on the contrary it seemed to be normalized. Results showed that the amount of conjugated linoleic acid produced by Lactobacillus rhamnosus PL60 was enough to produce an anti-obesity effect.en
dc.description.sponsorshipThis work was supported in part by CJ Food R&D institute, PL Bio Ltd., and Korea Research Foundation Grant (KRF-005-E00077) and the Brain Korea 21 Project.en
dc.language.isoen-
dc.publisherElsevieren
dc.subjectConjugated linoleic aciden
dc.subjectLactobacillus rhamnosusen
dc.subjectDiet induced obeseen
dc.subjectAnti-obesityen
dc.subjectMouseen
dc.titleHuman originated bacteria, Lactobacillus rhamnosus PL60, produce conjugated linoleic acid and show anti-obesity effects in diet-induced obese miceen
dc.typeArticleen
dc.contributor.AlternativeAuthor이회영-
dc.contributor.AlternativeAuthor박종환-
dc.contributor.AlternativeAuthor석승혁-
dc.contributor.AlternativeAuthor백민원-
dc.contributor.AlternativeAuthor김동재-
dc.contributor.AlternativeAuthor이기은-
dc.contributor.AlternativeAuthor백경수-
dc.contributor.AlternativeAuthor이연희-
dc.contributor.AlternativeAuthor박재학-
dc.identifier.doi10.1016/j.bbalip.2006.05.007-
Appears in Collections:
College of Veterinary Medicine (수의과대학)Dept. of Veterinary Medicine (수의학과)Journal Papers (저널논문_수의학과)
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