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Neoplastic transformation and tumorigenesis associated with overexpression of imup-1 and imup-2 genes in cultured NIH/3T3 mouse fibroblasts
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Ryoo, Zae Young | - |
dc.contributor.author | Jung, Boo Kyoung | - |
dc.contributor.author | Lee, Sang Ryeul | - |
dc.contributor.author | Kim, Myoung Ok | - |
dc.contributor.author | Kim, Sung Hyun | - |
dc.contributor.author | Kim, Hyo Jin | - |
dc.contributor.author | Ahn, Jung Yong | - |
dc.contributor.author | Lee, Tae-Hoon | - |
dc.contributor.author | Cho, Youl Hee | - |
dc.contributor.author | Park, Jae Hak | - |
dc.contributor.author | Kim, Jin Kyeoung | - |
dc.date.accessioned | 2009-08-07T08:04:37Z | - |
dc.date.available | 2009-08-07T08:04:37Z | - |
dc.date.issued | 2006-08-31 | - |
dc.identifier.citation | Biochem Biophys Res Commun. 349 (2006) 995–1002 | en |
dc.identifier.issn | 0006-291X | - |
dc.identifier.issn | http://dx.doi.org/10.1016/j.bbrc.2006.08.137 | - |
dc.identifier.uri | https://hdl.handle.net/10371/6539 | - |
dc.description.abstract | Immortalization-upregulated protein 1 (IMUP-1) and immortalization-upregulated protein 2 (IMUP-2) genes have been recently
cloned and are known to be involved in SV40-mediated immortalization. IMUP-1 and IMUP-2 genes were strongly expressed in various cancer cell lines and tumors, suggesting the possibility that they might be involved in tumorigenicity. To directly elucidate the functional role of IMUP-1 and IMUP-2 on neoplastic transformation and tumorigenicity, we stably transfected IMUP-1 and IMUP-2 into NIH/ 3T3 mouse fibroblast cells. Cellular characteristics of the neoplastic transformation were assessed by transformation foci, growth in soft agar, and tumor development in nude mice. We found that IMUP-1 and IMUP-2 overexpressing cells showed altered growth properties, anchorage-independent growth in soft agar and inducing tumor in nude mice. Furthermore, IMUP-1 and IMUP-2 transformants proliferated in reduced serum and shortened cell cycle. These results suggest that ectopic overexpression of IMUP-1 and IMUP-2 may play an important role in acquiring a transformed phenotype, tumorigenicity in vivo, and be related to cellular proliferation. | en |
dc.description.sponsorship | This work was supported by a grant of Biogreen 21
(200203706), Republic of Korea. | en |
dc.language.iso | en | - |
dc.publisher | Elsevier | en |
dc.subject | IMUP-1 | en |
dc.subject | IMUP-2 | en |
dc.subject | SV40 | en |
dc.subject | Tumorigenicity | en |
dc.subject | Fibroblast | en |
dc.title | Neoplastic transformation and tumorigenesis associated with overexpression of imup-1 and imup-2 genes in cultured NIH/3T3 mouse fibroblasts | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 류재웅 | - |
dc.contributor.AlternativeAuthor | 정부경 | - |
dc.contributor.AlternativeAuthor | 이상렬 | - |
dc.contributor.AlternativeAuthor | 김명옥 | - |
dc.contributor.AlternativeAuthor | 김성현 | - |
dc.contributor.AlternativeAuthor | 김효진 | - |
dc.contributor.AlternativeAuthor | 안정용 | - |
dc.contributor.AlternativeAuthor | 이태훈 | - |
dc.contributor.AlternativeAuthor | 조율희 | - |
dc.contributor.AlternativeAuthor | 박재학 | - |
dc.contributor.AlternativeAuthor | 김진경 | - |
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