Double-stranded RNA induces inflammatory gene expression in schwann cells: Implication in the Wallerian degeneration

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Lee, Hyunkyoung; Park, Chanhee; Choi, Se-Young; Oh, Seog Bae; Park, Kyungpyo; Kim, Joong-Soo; Lee, Sung Joong

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Korean J Physiol Pharmacol 8:253-258
Schwann cellsToll-like receptoriNOSRANTESTNF-αiSC
Schwann cells play an important role in peripheral nerve regeneration. Upon neuronal injury, activated
Schwann cells clean up the myelin debris by phagocytosis, and promote neuronal survival and
axon outgrowth by secreting various neurotrophic factors. However, it is unclear how the nerve injury
induces Schwann cell activation. Recently, it was reported that certain cytoplasmic molecules, which
are secreted by cells undergoing necrotic cell death, induce immune cell activation via the toll-like
receptors (TLRs). This suggests that the TLRs expressed on Schwann cells may recognize nerve damage
by binding to the endogenous ligands secreted by the damaged nerve, thereby inducing Schwann cell
activation. Accordingly, this study was undertaken to examine the expression and the function of the
TLRs on primary Schwann cells and iSC, a rat Schwann cell line. The transcripts of TLR2, 3, 4, and
9 were detected on the primary Schwann cells as well as on iSC. The stimulation of iSC with poly
(I:C), a synthetic ligand for the TLR3, induced the expression of TNF-α and RANTES. In addition,
poly (I:C) stimulation induced the iNOS expression and nitric oxide secretion in iSC. These results
suggest that the TLRs may be involved in the inflammatory activation of Schwann cells, which is
observed during Wallerian degeneration after a peripheral nerve injury.
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College of Dentistry/School of Dentistry (치과대학/치의학대학원)Dept. of Dentistry (치의학과)Journal Papers (저널논문_치의학과)
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