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Molecular cloning of leukotactin-1: A novel human beta-chemokine, a chemoattractant for neutrophils, monocytes, and lymphocytes, and a potent agonist at CC chemokine receptors 1 and 3
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Youn, BS | - |
dc.contributor.author | Zhang, SM | - |
dc.contributor.author | Lee, EK | - |
dc.contributor.author | Park, DH | - |
dc.contributor.author | Broxmeyer, HE | - |
dc.contributor.author | Murphy, PM | - |
dc.contributor.author | Locati, M | - |
dc.contributor.author | Pease, JE | - |
dc.contributor.author | Kim, KK | - |
dc.contributor.author | Antol, K | - |
dc.contributor.author | Kwon, BS | - |
dc.date.accessioned | 2010-05-17T10:54:42Z | - |
dc.date.available | 2010-05-17T10:54:42Z | - |
dc.date.issued | 1997 | - |
dc.identifier.citation | Journal of Immunology 159:5201-5205 | en |
dc.identifier.issn | 0022-1767 | - |
dc.identifier.uri | https://hdl.handle.net/10371/66615 | - |
dc.description.abstract | A new member of human beta-chemokine cDNA was isolated and named leukotactin-1 (Lkn-1). Lkn-1, along with murine macrophage inflammatory protein-related protein-1 and -2, defines a subgroup of beta-chemokines based on two conserved cysteines in addition to the four others conserved in all beta-chemokines. The putative mature Lkn-1 is composed of 92 amino acids with a calculated m.w. of 10,162. The Lkn-1 gene was mapped to human chromosome 17, region q12. Recombinant Lkn-1 was a potent chemoattractant for neutrophils, monocytes, and lymphocytes and induced calcium flux in these cells. Lkn-1 specifically induced calcium flux in CCR1- and CCR3-expressing HOS cell lines. Lkn-1 suppressed colony formation by human granulocyte-macrophage, erythroid, and multipotential progenitor cells stimulated by combinations of growth factors. Hence, we have isolated and characterized a human C6 beta- chemokine that is a potent agonist at CCR1 and CCR3 and shows broad biologic activities, including leukocyte chemoattraction. | en |
dc.language.iso | en | en |
dc.publisher | American Association of Immunologists | en |
dc.title | Molecular cloning of leukotactin-1: A novel human beta-chemokine, a chemoattractant for neutrophils, monocytes, and lymphocytes, and a potent agonist at CC chemokine receptors 1 and 3 | en |
dc.type | Article | en |
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