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CpG oligodeoxynucleotides induce expression of proinflammatory cytokines and chemokines in astrocytes: the role of c-Jun N-terminal kinase in CpG ODN-mediated NF-κB activation
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, Soojin | - |
dc.contributor.author | Hong, Jinpyo | - |
dc.contributor.author | Choi, Se-Young | - |
dc.contributor.author | Oh, Seog Bae | - |
dc.contributor.author | Park, Kyungpyo | - |
dc.contributor.author | Kim, Joong Soo | - |
dc.contributor.author | Karin, Michael | - |
dc.contributor.author | Lee, Sung Joong | - |
dc.date.accessioned | 2010-05-17T11:05:26Z | - |
dc.date.available | 2010-05-17T11:05:26Z | - |
dc.date.issued | 2004-08 | - |
dc.identifier.citation | Journal of Neuroimmunology 153, 50–63 | en |
dc.identifier.issn | 0165-5728 | - |
dc.identifier.uri | https://hdl.handle.net/10371/66621 | - |
dc.description.abstract | Bacterial DNA and synthetic oligodeoxynucleotides (ODN) containing unmethylated CpG motifs stimulate the cells of the innate immune system through a specific receptor called Toll-like receptor-9 (TLR9). It was reported that CpG ODN stimulation induces activation of astrocytes and microglia. However, the precise intracellular signaling pathways that lead to this glial cell activation have not been clearly elucidated. In this study, we found that CpG ODN induce mRNA expression of adhesion molecules and matrix metalloproteinase-9 (MMP-9), as well as proinflammatory cytokines and chemokines, in mouse astrocytes. CpG ODN stimulation in astrocytes induces the activation of IκB kinase (IKK) and c-Jun N-terminal kinase (JNK), whereas it inhibits the constitutive ERK1/2 activation. The abrogation of JNK activity using a pharmacological inhibitor showed that JNK activation is essential for the induction of cytokine and chemokine gene expression. This effect of JNK does not require the phosphorylation of c-Jun; rather, it works via the potentiation of NF-κB signaling. | en |
dc.description.sponsorship | This study was supported by grants from the Ministry of Health and Welfare, Republic of Korea (03-PJ1-PG3-21300-0008) and the National Institute of Health (NIH AI43477 and NIH ES06376). | en |
dc.language.iso | en | - |
dc.publisher | Elsevier | en |
dc.subject | TLR9 | en |
dc.subject | CpG ODN | en |
dc.subject | Astrocytes | en |
dc.subject | JNK | en |
dc.subject | NF-κB | en |
dc.title | CpG oligodeoxynucleotides induce expression of proinflammatory cytokines and chemokines in astrocytes: the role of c-Jun N-terminal kinase in CpG ODN-mediated NF-κB activation | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 이수진 | - |
dc.contributor.AlternativeAuthor | 홍진표 | - |
dc.contributor.AlternativeAuthor | 최세영 | - |
dc.contributor.AlternativeAuthor | 오석배 | - |
dc.contributor.AlternativeAuthor | 박경표 | - |
dc.contributor.AlternativeAuthor | 김중수 | - |
dc.contributor.AlternativeAuthor | 이성중 | - |
dc.identifier.doi | 10.1016/j.jneuroim.2004.04.013 | - |
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