부자의 강심성분 검색에 관한 연구

Abstract

The positive inotropic and the hemodynamic effects of Aconiti tuber butanol fraction were studied in excised rat auricle and in intact anesthetized rabbit. In contrast with digitalis cardiac glycoside, Aconiti tuber butanol fraction showed strong positive inotropic effect on rat auricle, which was not influenced by varying concentrations of potassium in Krebs solution. High calcium concentrations in the nutrient medium reduced the positive inotropic effect of Aco.. niti tuber butanol fraction, while low calcium shoo wed to increase the positive inotropic action. This synergistic effect of calcium with Aconiti tuber butanol fraction was similar to that of digitalis glyco.. side with calcium in a digitalis susceptible cardiac muscle preparation. In the hemodynamics of anesthetized rabbit heart rate, left ventricular diastolic pressure and systemic arterial pressure were slightly reduced by Aconiti tuber butanol fraction. Cardiac output seemed to be increased by Aconiti, but it was variable and insignificant.