S-Space College of Medicine/School of Medicine (의과대학/대학원) Dept. of Medicine (의학과) The Seoul Journal of Medicine The Seoul Journal of Medicine Vol. 24 No.1 (1983)
Dexamethasone 억제감사의 정신과적 진단 가치에 관한 연구
Utilization of Dexamethasone Suppression Test (DST) in Psychiatric Diagnosis
- 정도언; 우종인; 이정균
- Issue Date
- 서울대학교 의과대학
- Seoul J Med, Vol.24 No.1, pp. 116-121
- 39 subjects (20 normal controls and 19 major
depressive patients) underwent an DST to prove the
applicability of the test for the diagnosis of major
depressive disorder CDSM-II!).
Serum cortisol concentrations were determined in
duplicate by radioimmunoassay using Amerlex cortisol
RIA kit obtained from Amersham International
The results and conclusions are as follows: 1. Pre-dexamethasone serum cortisol concentrations
were most increased at 8 : 00 hour decreasing mostly
at 23 : 30 both in normal controls and depressive
patients, lessening the probability of disrupted eireadian
rhythm in the latter.
2. No significant differences of pre-dexamethasone
cortisol levels were found between normal controls
and depressive patients(by Student's t-test),
3. Significantly decreased suppressibility of serum
cortisol levels occurred in depressive patients within
24 hour after dexamethasone (Irng) administration
at S : 00 and 16: 00 hour. No difference was found
at 23 : 30 hour (by analysis of covariance).
4. The cortisol values after dexamethasone were
definitely more specific as discriminators than the
corresponding values before dexamethasone.
5. Significant intergroup differences were revealed
in the distribution of suppressors and nonsupressors
only when the criterion value of serum cortisol level
for nonsuppression was supposed to be above Spg/dl
(sensitivity: 26%). That was thought to be due to
a limited number of study subjects.
6. Differences in age, sex, body weight, psychopathology,
family history of mental illness, recurring
episodes of major depression, or associated psychotic
features had no bearing upon the distribution of
suppressors and nonsuppressors (by Fisher's exact