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Aminostyrylbenzofuran derivatives as potent inhibitors for Abeta fibril formation
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Byun, Ji Hun | - |
dc.contributor.author | Kim, HyeYun | - |
dc.contributor.author | Kim, YoungSoo | - |
dc.contributor.author | Mook-Jung, Inhee | - |
dc.contributor.author | Kim, Dong Jin | - |
dc.contributor.author | Lee, Won Koo | - |
dc.contributor.author | Yoo, Kyung Ho | - |
dc.date.accessioned | 2010-06-07 | - |
dc.date.available | 2010-06-07 | - |
dc.date.issued | 2008-09-17 | - |
dc.identifier.citation | Bioorganic & Medicinal Chemistry Letters 2008, 18(20), 5591-5593 | en |
dc.identifier.issn | 1464-3405 (Electronic) | - |
dc.identifier.uri | http://www.sciencedirect.com/science?_ob=MImg&_imagekey=B6TF9-4TC34V1-3-9&_cdi=5221&_user=168665&_orig=search&_coverDate=10%2F15%2F2008&_sk=999819979&view=c&wchp=dGLzVzz-zSkWA&md5=6ffffd80447af670bc66a64bbc6050bc&ie=/sdarticle.pdf | - |
dc.identifier.uri | https://hdl.handle.net/10371/67455 | - |
dc.description.abstract | The synthesis of a novel series of aminostyrylbenzofuran derivatives 1a-w and their inhibitory activities for Abeta fibril formation were described. All the synthesized compounds were evaluated by thioflavin T (ThT) assay and displayed potent inhibitory activities for Abeta fibril formation. Among them, compounds 1i and 1q exhibited excellent inhibitory activities (IC(50)=0.07 and 0.08 microM, respectively) than those of Curcumin (IC(50)=0.80 microM) and IMSB (IC(50)=8.00 microM) as reference compounds. Both compounds were selected as promising candidates for further biological evaluation. | en |
dc.language.iso | en | en |
dc.publisher | Elsevier | en |
dc.subject | Alzheimer Disease/drug therapy/metabolism | en |
dc.subject | Amyloid beta-Protein/antagonists & inhibitors/*chemistry | en |
dc.subject | Benzofurans/*chemical synthesis/pharmacology | en |
dc.subject | Benzoxazoles/chemistry | en |
dc.subject | Chemistry, Pharmaceutical/*methods | en |
dc.subject | Curcumin/chemical synthesis/pharmacology | en |
dc.subject | Drug Design | en |
dc.subject | Electrons | en |
dc.subject | Humans | en |
dc.subject | Inhibitory Concentration 50 | en |
dc.subject | Models, Chemical | en |
dc.subject | Peptide Fragments/*antagonists & inhibitors/chemistry | en |
dc.subject | Structure-Activity Relationship | en |
dc.subject | Styrenes/*chemical synthesis/pharmacology | en |
dc.subject | Thiazoles/chemistry | en |
dc.title | Aminostyrylbenzofuran derivatives as potent inhibitors for Abeta fibril formation | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 변지훈 | - |
dc.contributor.AlternativeAuthor | 김혜연 | - |
dc.contributor.AlternativeAuthor | 김영수 | - |
dc.contributor.AlternativeAuthor | 김동진 | - |
dc.contributor.AlternativeAuthor | 이원구 | - |
dc.contributor.AlternativeAuthor | 유경호 | - |
dc.identifier.doi | 10.1016/j.bmcl.2008.08.111 | - |
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