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Aminostyrylbenzofuran derivatives as potent inhibitors for Abeta fibril formation

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dc.contributor.authorByun, Ji Hun-
dc.contributor.authorKim, HyeYun-
dc.contributor.authorKim, YoungSoo-
dc.contributor.authorMook-Jung, Inhee-
dc.contributor.authorKim, Dong Jin-
dc.contributor.authorLee, Won Koo-
dc.contributor.authorYoo, Kyung Ho-
dc.date.accessioned2010-06-07-
dc.date.available2010-06-07-
dc.date.issued2008-09-17-
dc.identifier.citationBioorganic & Medicinal Chemistry Letters 2008, 18(20), 5591-5593en
dc.identifier.issn1464-3405 (Electronic)-
dc.identifier.urihttp://www.sciencedirect.com/science?_ob=MImg&_imagekey=B6TF9-4TC34V1-3-9&_cdi=5221&_user=168665&_orig=search&_coverDate=10%2F15%2F2008&_sk=999819979&view=c&wchp=dGLzVzz-zSkWA&md5=6ffffd80447af670bc66a64bbc6050bc&ie=/sdarticle.pdf-
dc.identifier.urihttps://hdl.handle.net/10371/67455-
dc.description.abstractThe synthesis of a novel series of aminostyrylbenzofuran derivatives 1a-w and their inhibitory activities for Abeta fibril formation were described. All the synthesized compounds were evaluated by thioflavin T (ThT) assay and displayed potent inhibitory activities for Abeta fibril formation. Among them, compounds 1i and 1q exhibited excellent inhibitory activities (IC(50)=0.07 and 0.08 microM, respectively) than those of Curcumin (IC(50)=0.80 microM) and IMSB (IC(50)=8.00 microM) as reference compounds. Both compounds were selected as promising candidates for further biological evaluation.en
dc.language.isoenen
dc.publisherElsevieren
dc.subjectAlzheimer Disease/drug therapy/metabolismen
dc.subjectAmyloid beta-Protein/antagonists & inhibitors/*chemistryen
dc.subjectBenzofurans/*chemical synthesis/pharmacologyen
dc.subjectBenzoxazoles/chemistryen
dc.subjectChemistry, Pharmaceutical/*methodsen
dc.subjectCurcumin/chemical synthesis/pharmacologyen
dc.subjectDrug Designen
dc.subjectElectronsen
dc.subjectHumansen
dc.subjectInhibitory Concentration 50en
dc.subjectModels, Chemicalen
dc.subjectPeptide Fragments/*antagonists & inhibitors/chemistryen
dc.subjectStructure-Activity Relationshipen
dc.subjectStyrenes/*chemical synthesis/pharmacologyen
dc.subjectThiazoles/chemistryen
dc.titleAminostyrylbenzofuran derivatives as potent inhibitors for Abeta fibril formationen
dc.typeArticleen
dc.contributor.AlternativeAuthor변지훈-
dc.contributor.AlternativeAuthor김혜연-
dc.contributor.AlternativeAuthor김영수-
dc.contributor.AlternativeAuthor김동진-
dc.contributor.AlternativeAuthor이원구-
dc.contributor.AlternativeAuthor유경호-
dc.identifier.doi10.1016/j.bmcl.2008.08.111-
Appears in Collections:
College of Medicine/School of Medicine (의과대학/대학원)Dept. of Biochemistry & Molecular Biology (생화학교실)Journal Papers (저널논문_생화학교실)
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