S-Space College of Medicine/School of Medicine (의과대학/대학원) Dept. of Biochemistry & Molecular Biology (생화학교실) Journal Papers (저널논문_생화학교실)
Inhibitor of differentiation 4 drives brain tumor-initiating cell genesis through cyclin E and notch signaling
- Jeon, Hye-Min; Jin, Xun; Lee, Joong-Seob; Oh, Se-Yeong; Sohn, Young-Woo; Park, Hyo-Jung; Joo, Kyeung Min; Park, Woong-Yang; Nam, Do-Hyun; DePinho, Ronald A; Chin, Lynda; Kim, Hyunggee
- Issue Date
- Cold Spring Harbor Laboratory Press
- Genes Dev. 22(15): 2028-2033
- Animals; Astrocytes/cytology/*physiology; Calcium-Binding Proteins/metabolism; Cell Culture Techniques; Cell Line, Tumor; *Cell Transformation, Neoplastic; Cells, Cultured; Cerebral Cortex/cytology; Cyclin E/*metabolism; Glioblastoma/pathology; Humans; Inhibitor of Differentiation Proteins/*metabolism; Intercellular Signaling Peptides and Proteins/metabolism; Membrane Proteins/metabolism; Mice; Mice, Knockout; RNA, Messenger/metabolism; Receptor, Notch1/genetics/*metabolism; Signal Transduction/genetics/*physiology
- Cellular origins and genetic factors governing the genesis and maintenance of glioblastomas (GBM) are not well understood. Here, we report a pathogenetic role of the developmental regulator Id4 (inhibitor of differentiation 4) in GBM. In primary murine Ink4a/Arf(-/-) astrocytes, and human glioma cells, we provide evidence that enforced Id4 can drive malignant transformation by stimulating increased cyclin E to produce a hyperproliferative profile and by increased Jagged1 expression with Notch1 activation to drive astrocytes into a neural stem-like cell state. Thus, Id4 plays an integral role in the transformation of astrocytes via its combined actions on two-key cell cycle and differentiation regulatory molecules.
- 0890-9369 (Print)
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