S-Space College of Medicine/School of Medicine (의과대학/대학원) Dept. of Biochemistry & Molecular Biology (생화학교실) Journal Papers (저널논문_생화학교실)
Inhibitor of differentiation 4 drives brain tumor-initiating cell genesis through cyclin E and notch signaling
- Issue Date
- Cold Spring Harbor Laboratory Press
- Genes Dev. 22(15): 2028-2033
- Animals ; Astrocytes/cytology/*physiology ; Calcium-Binding Proteins/metabolism ; Cell Culture Techniques ; Cell Line, Tumor ; Cells, Cultured ; Cerebral Cortex/cytology ; Cyclin E/*metabolism ; Glioblastoma/pathology ; Humans ; Inhibitor of Differentiation Proteins/*metabolism ; Intercellular Signaling Peptides and Proteins/metabolism ; Membrane Proteins/metabolism ; Mice ; Mice, Knockout ; RNA, Messenger/metabolism ; Receptor, Notch1/genetics/*metabolism ; Signal Transduction/genetics/*physiology ; Cell Transformation, Neoplastic
- Cellular origins and genetic factors governing the genesis and maintenance of glioblastomas (GBM) are not well understood. Here, we report a pathogenetic role of the developmental regulator Id4 (inhibitor of differentiation 4) in GBM. In primary murine Ink4a/Arf(-/-) astrocytes, and human glioma cells, we provide evidence that enforced Id4 can drive malignant transformation by stimulating increased cyclin E to produce a hyperproliferative profile and by increased Jagged1 expression with Notch1 activation to drive astrocytes into a neural stem-like cell state. Thus, Id4 plays an integral role in the transformation of astrocytes via its combined actions on two-key cell cycle and differentiation regulatory molecules.
- 0890-9369 (Print)
- Files in This Item: There are no files associated with this item.