S-Space College of Medicine/School of Medicine (의과대학/대학원) Dept. of Biochemistry & Molecular Biology (생화학교실) Journal Papers (저널논문_생화학교실)
Esco2 is a novel corepressor that associates with various chromatin modifying enzymes
- Kim, Beom-Jun; Kang, Kyung-Min; Jung, Sung Yun; Choi, Hyun-Kyung; Seo, Jong-Hun; Chae, Ji-Hye; Cho, Eun-Jung; Youn, Hong-Duk; Qin, Jun; Kim, Seong-Tae
- Issue Date
- Biochemical and Biophysical Research Communications 372 (2008) 298-304
- Acetyltransferases/genetics/*metabolism; Cell Line; Chromatin/*enzymology; Chromosomal Proteins, Non-Histone/genetics/*metabolism; Hela Cells; Histone-Lysine N-Methyltransferase/genetics/*metabolism; Histones/metabolism; Humans; Methyltransferases/metabolism; Protein Methyltransferases/metabolism; Repressor Proteins/genetics/*metabolism; *Transcription, Genetic
- Accurate chromosome segregation during cell division requires that sister chromatids are kept together by cohesin complex until anaphase, when the chromatids separate and distribute to the two daughter cells. Esco2 is an acetyltransferase that is required for the establishment of sister chromatid cohesion during S phase. Here, we report that Esco2 interacts with several component proteins of the CoREST complex, including a transcription corepressor CoREST, histone demethlyase LSD1, HDAC1, HDAC2, BRAF35, and PHF21A. Esco2 also interacts with various histone methyltransferases Suv39h1, SETDB1 and G9a. Esco2 complex purified from HeLa nuclear extract possesses histone H3 K9 methylation activity and functions as a transcription repressor. Esco2 fused to Gal4 DNA binding domain represses transcription by increasing methylation of histone H3 K9 in the promoter region. These results suggest a novel function of Esco2 in transcription repression through modulation of the chromatin structure.
- 1090-2104 (Electronic)
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