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Esco2 is a novel corepressor that associates with various chromatin modifying enzymes

Cited 23 time in Web of Science Cited 22 time in Scopus
Authors
Kim, Beom-Jun; Kang, Kyung-Min; Jung, Sung Yun; Choi, Hyun-Kyung; Seo, Jong-Hun; Chae, Ji-Hye; Cho, Eun-Jung; Youn, Hong-Duk; Qin, Jun; Kim, Seong-Tae
Issue Date
2008-05-27
Publisher
Elsevier
Citation
Biochemical and Biophysical Research Communications 372 (2008) 298-304
Keywords
Acetyltransferases/genetics/*metabolismCell LineChromatin/*enzymologyChromosomal Proteins, Non-Histone/genetics/*metabolismHela CellsHistone-Lysine N-Methyltransferase/genetics/*metabolismHistones/metabolismHumansMethyltransferases/metabolismProtein Methyltransferases/metabolismRepressor Proteins/genetics/*metabolism*Transcription, Genetic
Abstract
Accurate chromosome segregation during cell division requires that sister chromatids are kept together by cohesin complex until anaphase, when the chromatids separate and distribute to the two daughter cells. Esco2 is an acetyltransferase that is required for the establishment of sister chromatid cohesion during S phase. Here, we report that Esco2 interacts with several component proteins of the CoREST complex, including a transcription corepressor CoREST, histone demethlyase LSD1, HDAC1, HDAC2, BRAF35, and PHF21A. Esco2 also interacts with various histone methyltransferases Suv39h1, SETDB1 and G9a. Esco2 complex purified from HeLa nuclear extract possesses histone H3 K9 methylation activity and functions as a transcription repressor. Esco2 fused to Gal4 DNA binding domain represses transcription by increasing methylation of histone H3 K9 in the promoter region. These results suggest a novel function of Esco2 in transcription repression through modulation of the chromatin structure.
ISSN
1090-2104 (Electronic)
Language
English
URI
http://www.sciencedirect.com/science?_ob=MImg&_imagekey=B6WBK-4SJPVWR-5-9&_cdi=6713&_user=168665&_orig=search&_coverDate=07%2F25%2F2008&_sk=996279997&view=c&wchp=dGLzVzz-zSkWz&md5=0dc16d2e48022a21418f525a06b78de9&ie=/sdarticle.pdf

http://hdl.handle.net/10371/67484
DOI
https://doi.org/10.1016/j.bbrc.2008.05.056
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College of Medicine/School of Medicine (의과대학/대학원)Dept. of Biochemistry & Molecular Biology (생화학교실)Journal Papers (저널논문_생화학교실)
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