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Selective COX-2 inhibitors modulate cellular senescence in human dermal fibroblasts in a catalytic activity-independent manner
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, So Ra | - |
dc.contributor.author | Park, Jung Hae | - |
dc.contributor.author | Lee, Mi Eun | - |
dc.contributor.author | Park, Jeong Soo | - |
dc.contributor.author | Park, Sang Chul | - |
dc.contributor.author | Han, Jeong A | - |
dc.date.accessioned | 2010-06-07T01:31:05Z | - |
dc.date.available | 2010-06-07T01:31:05Z | - |
dc.date.issued | 2008-10-14 | - |
dc.identifier.citation | Mech Ageing Dev. 129(12), 706-713 | en |
dc.identifier.issn | 0047-6374 (Print) | - |
dc.identifier.uri | http://www.sciencedirect.com/science?_ob=MImg&_imagekey=B6T31-4TGS7BY-1-F&_cdi=4933&_user=168665&_orig=search&_coverDate=12%2F31%2F2008&_sk=998709987&view=c&wchp=dGLbVzW-zSkzV&md5=60e04ee8973bd09337f434d54e4398b2&ie=/sdarticle.pdf | - |
dc.identifier.uri | https://hdl.handle.net/10371/67492 | - |
dc.description.abstract | It has been recently proposed that pro-inflammatory genes such as cyclooxygenase-2 (COX-2) play a key role in the aging process. However, it remains unclear whether the pro-inflammatory activity of COX-2 is involved in the aging process and whether COX-2 inhibitors prevent aging. We therefore examined the effect of COX-2 inhibitors on aging in the cellular senescence model of human dermal fibroblasts (HDFs). While the catalytic activity of COX-2 was observed to increase in the senescence process, we found that among three selective COX-2 inhibitors studied, only NS-398 inhibited the senescence whereas celecoxib and nimesulide accelerated the senescence. Non-selective COX inhibitors including aspirin, ibuprofen and flurbiprofen accelerated the senescence. The senescence-regulating effect of selective COX-2 inhibitors had no correlation with cellular reactive oxygen species levels, NF-kappaB activities or protein levels of p53 and p21. We instead found that selective COX-2 inhibitors regulate caveolin-1 expression at transcriptional levels, which was closely associated with the inhibitors' effect on the senescence. Collectively, these results suggest that COX-2 catalytic activity does not mediate HDF senescence and that selective COX-2 inhibitors modulate HDF senescence by a catalytic activity-independent mechanism. | en |
dc.language.iso | en | en |
dc.publisher | Elsevier | en |
dc.subject | Aspirin/pharmacology | en |
dc.subject | Caveolin 1/metabolism | en |
dc.subject | Cell Aging/*drug effects/*physiology | en |
dc.subject | Cells, Cultured | en |
dc.subject | Cyclin-Dependent Kinase Inhibitor p21/metabolism | en |
dc.subject | Cyclooxygenase 1/metabolism | en |
dc.subject | Cyclooxygenase 2/*metabolism | en |
dc.subject | Cyclooxygenase 2 Inhibitors/*pharmacology | en |
dc.subject | Cyclooxygenase Inhibitors/pharmacology | en |
dc.subject | Fibroblasts/cytology/drug effects/metabolism | en |
dc.subject | Flurbiprofen/pharmacology | en |
dc.subject | Humans | en |
dc.subject | Ibuprofen/pharmacology | en |
dc.subject | Kinetics | en |
dc.subject | Models, Biological | en |
dc.subject | NF-kappa B/metabolism | en |
dc.subject | Nitrobenzenes/pharmacology | en |
dc.subject | Pyrazoles/pharmacology | en |
dc.subject | Reactive Oxygen Species/metabolism | en |
dc.subject | Skin/cytology/drug effects/metabolism | en |
dc.subject | Skin Aging/drug effects/physiology | en |
dc.subject | Sulfonamides/pharmacology | en |
dc.subject | Tumor Suppressor Protein p53/metabolism | en |
dc.title | Selective COX-2 inhibitors modulate cellular senescence in human dermal fibroblasts in a catalytic activity-independent manner | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 김소라 | - |
dc.contributor.AlternativeAuthor | 박정희 | - |
dc.contributor.AlternativeAuthor | 이미은 | - |
dc.contributor.AlternativeAuthor | 박정수 | - |
dc.contributor.AlternativeAuthor | 박상철 | - |
dc.contributor.AlternativeAuthor | 한정아 | - |
dc.identifier.doi | 10.1016/j.mad.2008.09.003 | - |
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