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Basal and UV-induced MMP-1 expression are inhibited by p53 in human dermal fibroblasts
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Sangmin | - |
dc.contributor.author | Lee, Youngae | - |
dc.contributor.author | Lee, Dong Hun | - |
dc.contributor.author | Kim, Yoonkyung | - |
dc.contributor.author | Cho, Kwang Hyun | - |
dc.contributor.author | Chung, Jin Ho | - |
dc.date.accessioned | 2010-06-07T05:32:48Z | - |
dc.date.available | 2010-06-07T05:32:48Z | - |
dc.date.issued | 2008-06-19 | - |
dc.identifier.citation | Exp Dermatol. 2008; 17(11): 939-945 | en |
dc.identifier.issn | 1600-0625 (Electronic) | - |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=18557930 | - |
dc.identifier.uri | https://hdl.handle.net/10371/67537 | - |
dc.description.abstract | Ultraviolet (UV) triggers induction of matrix metalloproteinase-1 (MMP-1) and also induces the rapid appearance of p53 protein in the epidermis and dermal fibroblasts. However, little is known about the role of p53 on MMP-1 expression in human skin. Here, we investigated the effects of p53 on basal and UV-induced MMP-1 in human dermal fibroblasts. To verify the role of p53 on MMP-1 expression, adenoviral p53 (Ad-p53) gene was infected to human dermal fibroblasts. Our results showed that basal and UV-induced MMP-1 expression was prevented by Ad-p53. In contrast, p53 inhibitor, pifithrin-alpha augmented the UV-induced MMP-1 expression. On the other hand, p53 activator, etoposide, decreased the MMP-1 expression in both normal and p53-overexpressed cells. In addition, MMP-1 expression was not changed by etoposide and/or pifithrin-alpha in HaCaT cells, which have mutation of p53. Taken together, we suggest that p53 inhibits basal and UV-induced MMP-1 expression in human dermal fibroblasts. | en |
dc.language.iso | en | en |
dc.publisher | Wiley-Blackwell | en |
dc.subject | Adenoviridae/genetics | en |
dc.subject | Benzothiazoles/pharmacology | en |
dc.subject | Blotting, Western | en |
dc.subject | Cells, Cultured | en |
dc.subject | Dermis/cytology/metabolism | en |
dc.subject | Etoposide/pharmacology | en |
dc.subject | Fibroblasts/drug effects/*metabolism/radiation effects | en |
dc.subject | Humans | en |
dc.subject | Matrix Metalloproteinase 1/*metabolism | en |
dc.subject | Phosphorylation/drug effects/radiation effects | en |
dc.subject | Proto-Oncogene Proteins c-fos/metabolism | en |
dc.subject | Proto-Oncogene Proteins c-jun/metabolism | en |
dc.subject | Toluene/analogs & derivatives/pharmacology | en |
dc.subject | Transduction, Genetic | en |
dc.subject | Tumor Suppressor Protein p53/genetics/*physiology | en |
dc.subject | Young Adult | en |
dc.subject | Ultraviolet Rays | - |
dc.title | Basal and UV-induced MMP-1 expression are inhibited by p53 in human dermal fibroblasts | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 김상민 | - |
dc.contributor.AlternativeAuthor | 이영애 | - |
dc.contributor.AlternativeAuthor | 이동헌 | - |
dc.contributor.AlternativeAuthor | 김윤경 | - |
dc.contributor.AlternativeAuthor | 조광현 | - |
dc.contributor.AlternativeAuthor | 정진호 | - |
dc.identifier.doi | 10.1111/j.1600-0625.2008.00729.x | - |
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