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Effect of ginkgo biloba and dexamethasone in the treatment of 3-methylindole-induced anosmia mouse model

Cited 12 time in Web of Science Cited 12 time in Scopus
Issue Date
2008-07-01
Publisher
Oceanside Publications
Citation
Am J Rhinol. 22(3):292-296
Keywords
Anosmiadexamethasoneginkgo biloba3-methelindoleolfactory bulbolfactory marker proteinolfactory neuroepitheliumPlant Preparations/*therapeutic use
Abstract
BACKGROUND: Olfactory loss is a challenging disease. Although glucocorticoid is sometimes used for the treatment of anosmia, it has been reported that it potentiated neural damage in the early phase of treatment. This study is designed to identify the effect of ginkgo biloba, an antioxidant that acts as a free radical scavenger, in the treatment of olfactory injury aggravated by dexamethasone. METHODS: Anosmia mouse model was induced by i.p. injection of 3-methylindole (3-MI). Twenty-five mice were divided into one control group without anosmia and four anosmia treatment groups (given treatments of dexamethasone and/or ginkgo biloba). The effects of treatment were evaluated by behavioral test, Western blot, and immunohistochemistry 2 weeks after 3-MI injection. RESULTS: Induction of anosmia was confirmed by behavioral tests. The thickness and cell number of olfactory neuroepithelium were decreased more significantly in the dexamethasone treatment group than in the combination treatment group. The expression of olfactory marker protein (OMP) in olfactory epithelium was more decreased also in the dexamethasone treatment group than in the combination treatment group. The expression of OMP was decreased significantly in the olfactory bulbs of anosmia groups but there were no differences between the anosmia treatment groups. CONCLUSION: Dexamethasone treatment was associated with further deterioration of olfactory injury by 3-MI and it was recovered by combination treatment of dexamethasone and ginkgo biloba. The antioxidant effect of ginkgo biloba might play a role in restoration of olfactory loss and it was effective only when oxidative stress is maximized by dexamethasone.
ISSN
1050-6586 (Print)
Language
English
URI
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=18588762

http://docserver.ingentaconnect.com/deliver/connect/ocean/10506586/v22n3/s14.pdf?expires=1261631027&id=54109438&titleid=6152&accname=SEOUL+NATIONAL+UNIV+HOSPITAL&checksum=381C1B307EA8BE815F0F6544B91A8630

https://hdl.handle.net/10371/67538
DOI
https://doi.org/10.2500/ajr.2008.22.3167
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College of Medicine/School of Medicine (의과대학/대학원)Otorhinolaryngology (이비인후과학전공)Journal Papers (저널논문_이비인후과학전공)
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