Publications
Detailed Information
Effect of ginkgo biloba and dexamethasone in the treatment of 3-methylindole-induced anosmia mouse model
Cited 12 time in
Web of Science
Cited 12 time in Scopus
- Authors
- Issue Date
- 2008-07-01
- Publisher
- Oceanside Publications
- Citation
- Am J Rhinol. 22(3):292-296
- Keywords
- Anosmia ; dexamethasone ; ginkgo biloba ; 3-methelindole ; olfactory bulb ; olfactory marker protein ; olfactory neuroepithelium ; Plant Preparations/*therapeutic use
- Abstract
- BACKGROUND: Olfactory loss is a challenging disease. Although glucocorticoid is sometimes used for the treatment of anosmia, it has been reported that it potentiated neural damage in the early phase of treatment. This study is designed to identify the effect of ginkgo biloba, an antioxidant that acts as a free radical scavenger, in the treatment of olfactory injury aggravated by dexamethasone. METHODS: Anosmia mouse model was induced by i.p. injection of 3-methylindole (3-MI). Twenty-five mice were divided into one control group without anosmia and four anosmia treatment groups (given treatments of dexamethasone and/or ginkgo biloba). The effects of treatment were evaluated by behavioral test, Western blot, and immunohistochemistry 2 weeks after 3-MI injection. RESULTS: Induction of anosmia was confirmed by behavioral tests. The thickness and cell number of olfactory neuroepithelium were decreased more significantly in the dexamethasone treatment group than in the combination treatment group. The expression of olfactory marker protein (OMP) in olfactory epithelium was more decreased also in the dexamethasone treatment group than in the combination treatment group. The expression of OMP was decreased significantly in the olfactory bulbs of anosmia groups but there were no differences between the anosmia treatment groups. CONCLUSION: Dexamethasone treatment was associated with further deterioration of olfactory injury by 3-MI and it was recovered by combination treatment of dexamethasone and ginkgo biloba. The antioxidant effect of ginkgo biloba might play a role in restoration of olfactory loss and it was effective only when oxidative stress is maximized by dexamethasone.
- ISSN
- 1050-6586 (Print)
- Language
- English
- URI
- http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=18588762
http://docserver.ingentaconnect.com/deliver/connect/ocean/10506586/v22n3/s14.pdf?expires=1261631027&id=54109438&titleid=6152&accname=SEOUL+NATIONAL+UNIV+HOSPITAL&checksum=381C1B307EA8BE815F0F6544B91A8630
https://hdl.handle.net/10371/67538
- Files in This Item:
- There are no files associated with this item.
Item View & Download Count
Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.