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Effect of the CYP2C19 polymorphism on the eradication rate of Helicobacter pylori infection by 7-day triple therapy with regular proton pump inhibitor dosage

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dc.contributor.authorKang, Jung Mook-
dc.contributor.authorKim, Nayoung-
dc.contributor.authorLee, Dong Ho-
dc.contributor.authorPark, Young Soo-
dc.contributor.authorKim, Joo Sung-
dc.contributor.authorChang, In Jin-
dc.contributor.authorSong, In Sung-
dc.contributor.authorJung, Hyun Chae-
dc.date.accessioned2010-06-07T05:39:37Z-
dc.date.available2010-06-07T05:39:37Z-
dc.date.issued2008-07-19-
dc.identifier.citationJ Gastroenterol Hepatol. 2008; 23(8 Pt 1): 1287-91en
dc.identifier.issn1440-1746 (Electronic)-
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=18637061-
dc.identifier.urihttps://hdl.handle.net/10371/67540-
dc.description.abstractBACKGROUND AND AIM: Proton pump inhibitors (PPI) are mainly metabolized by cytochrome P450 2C19 (CYP2C19) in the liver. We investigated whether the CYP2C19 genotype plays a role in the eradication rate of Helicobacter pylori (H. pylori) infection in patients receiving pantoprazole- or esomeprazole-based triple therapy. METHODS: A total of 327 patients infected with H. pylori were treated with either pantoprazole or esomeprazole, plus amoxicillin and clarithromycin for 7 days. The presence of the CYP2C19 genotype was determined by pyrosequencing. RESULTS: The overall H. pylori eradication rate was 85%; 82.6% for the PAC regimen, and 88.3% for the EAC regimen; the differences were not statistically significant. The overall eradication rate in the poor metabolizer groups (PM) was significantly higher than in the extensive metabolizer groups (EM) (97.4% vs 83.3%; P = 0.016). The eradication rates in the EM and PM groups were 80.8% and 95.7% for the PAC regimen and 86.8% and 100% for the EAC regimen, respectively. CONCLUSION: The results of this study suggest that the CYP2C19 genotype status may play a role in the H. pylori eradication rate in patients receiving pantoprazole or esomeprazole-based triple therapy.en
dc.language.isoenen
dc.publisherWiley-Blackwellen
dc.subject2-Pyridinylmethylsulfinylbenzimidazoles/administration & dosageen
dc.subjectAdulten
dc.subjectAmoxicillin/administration & dosageen
dc.subjectAnti-Bacterial Agents/*administration & dosageen
dc.subjectAryl Hydrocarbon Hydroxylases/*geneticsen
dc.subjectClarithromycin/administration & dosageen
dc.subjectDrug Therapy, Combinationen
dc.subjectFemaleen
dc.subjectHelicobacter Infections/*drug therapy/*geneticsen
dc.subject*Helicobacter pylorien
dc.subjectHumansen
dc.subjectMaleen
dc.subjectMiddle Ageden
dc.subjectOmeprazole/administration & dosageen
dc.subjectPolymorphism, Geneticen
dc.subjectProton Pump Inhibitors/*administration & dosageen
dc.subjectTreatment Outcomeen
dc.titleEffect of the CYP2C19 polymorphism on the eradication rate of Helicobacter pylori infection by 7-day triple therapy with regular proton pump inhibitor dosageen
dc.typeArticleen
dc.contributor.AlternativeAuthor강정묵-
dc.contributor.AlternativeAuthor김나영-
dc.contributor.AlternativeAuthor이동호-
dc.contributor.AlternativeAuthor박영수-
dc.contributor.AlternativeAuthor김주성-
dc.contributor.AlternativeAuthor장인진-
dc.contributor.AlternativeAuthor송인성-
dc.contributor.AlternativeAuthor정현채-
dc.identifier.doi10.1111/j.1440-1746.2008.05392.x-
Appears in Collections:
College of Medicine/School of Medicine (의과대학/대학원)Pharmacology (약리학전공)Journal Papers (저널논문_약리학전공)
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