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Potential vulnerability markers within the affective domain in subjects at genetic and clinical high risk for schizophrenia

Cited 10 time in Web of Science Cited 12 time in Scopus
Authors
Lee, Seung Jae; Yoo, So Young; Kang, Do-Hyung; Lee, Kyung Jin; Ha, Tae Hyun; Wee, Whee; Lee, Ae-Ra; Kim, Nam Sick; Kwon, Jun Soo
Issue Date
2008-04-15
Publisher
Karger
Citation
Psychopathology. 2008;41(4):236-44. Epub 2008 Apr 11.
Keywords
Adaptation, PsychologicalAdolescentAdultAffectAffective Symptoms/diagnosis/*genetics/psychologyAwarenessChronic DiseaseFemaleFollow-Up StudiesGenetic Predisposition to Disease/genetics/psychologyHumansMalePersonality InventoryPsychiatric Status Rating ScalesSchizophrenia/diagnosis/*genetics*Schizophrenic PsychologySchizotypal Personality Disorder/diagnosis/genetics/psychology
Abstract
BACKGROUND: Relative to ample high-risk studies on neurocognitive function, only a few high-risk studies have examined affective functioning components as possible vulnerability markers. In this study, we comprehensively assessed baseline affective functioning in subjects at clinical high risk (CHR) and genetic high risk (GHR) for schizophrenia, and healthy controls (HC), and compared the results to elucidate possible vulnerability markers in the affective domain. METHODS: We studied 3 groups of subjects: those with CHR (n = 28) or GHR (n = 28) and a HC group (n = 24). Affective-process- and affective-content-related functioning were assessed using 5 emotion-related scales. RESULTS: In affective process, CHR subjects showed impairments in emotional awareness and mood repair, with some trend of impaired emotional expressivity as well as aggression control relative to either HC or GHR subjects, whereas GHR subjects showed only a trend of impairment in mood repair. In affective content, CHR subjects had less positive and more negative affect scores than the other 2 groups. CONCLUSIONS: These results correspond to previous findings of prodrome studies of schizophrenia and chronic schizophrenia and suggest that impaired mood repair and emotional awareness, as well as less positive and more negative affect may be potential candidates of vulnerability markers.
ISSN
1423-033X (Electronic)
Language
English
URI
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=18408419

http://content.karger.com/ProdukteDB/produkte.asp?Aktion=ShowPDF&ArtikelNr=000125557&Ausgabe=236910&ProduktNr=224276&filename=000125557.pdf

https://hdl.handle.net/10371/67721
DOI
https://doi.org/10.1159/000125557
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College of Medicine/School of Medicine (의과대학/대학원)Psychiatry (정신과학전공)Journal Papers (저널논문_정신과학전공)
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