Publications
Detailed Information
Immunohistochemical analysis of cell cycle-related molecules in gastric carcinoma: prognostic significance, correlation with clinicopathological parameters, proliferation and apoptosis
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, Kyung-Hee | - |
dc.contributor.author | Lee, Hee Eun | - |
dc.contributor.author | Cho, Sung Jin | - |
dc.contributor.author | Cho, Yu Jin | - |
dc.contributor.author | Lee, Hye Seung | - |
dc.contributor.author | Kim, Ji Hun | - |
dc.contributor.author | Nam, Seon Young | - |
dc.contributor.author | Chang, Mee Soo | - |
dc.contributor.author | Kim, Woo Ho | - |
dc.contributor.author | Lee, Byung Lan | - |
dc.date.accessioned | 2010-06-25T05:11:10Z | - |
dc.date.available | 2010-06-25T05:11:10Z | - |
dc.date.issued | 2008-12-20 | - |
dc.identifier.citation | Pathobiology. 2008;75(6):364-372 | en |
dc.identifier.issn | 1423-0291 (Electronic) | - |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=19096232 | - |
dc.identifier.uri | http://content.karger.com/ProdukteDB/produkte.asp?Aktion=ShowPDF&ArtikelNr=000164221&Ausgabe=241138&ProduktNr=224272&filename=000164221.pdf | - |
dc.identifier.uri | https://hdl.handle.net/10371/67789 | - |
dc.description.abstract | OBJECTIVE: We aimed to investigate the biological significance of cell cycle regulators in gastric carcinoma. METHODS: Immunohistochemistry and TUNEL staining were performed on tissue array slides containing 293 gastric carcinoma specimens. The relationship between the protein expression of each of the cell cycle regulators and prognosis, clinicopathological features, proliferation, or apoptosis was evaluated. RESULTS: The nuclear immunoreactivity for cyclin D1, cyclin E, p21, and p27 was observed in 22, 14, 31 and 27% of cases, respectively. The expression of cyclin D1, p21, or p27 positively correlated with early pTNM stages, tumor cell proliferation (represented by Ki-67 labeling) and good prognosis, whereas it inversely correlated with the lymph node metastasis (p < 0.05). On the other hand, p27 expression inversely correlated with the apoptosis index represented by TUNEL staining (p < 0.001). In addition, the expression of cyclin D1 positively correlated with that of p21 or p27 (p < 0.05). CONCLUSIONS: Our results showed that the expression of cyclin D1, p21 and p27, alone or in combination, are early events in gastric tumorigenesis and may serve as a candidate molecular marker for the early gastric carcinoma. | en |
dc.language.iso | en | en |
dc.publisher | Karger | en |
dc.subject | Adult | en |
dc.subject | Aged | en |
dc.subject | Aged, 80 and over | en |
dc.subject | Apoptosis | en |
dc.subject | Carcinoma/mortality/*pathology | en |
dc.subject | Cell Cycle | en |
dc.subject | Cell Cycle Proteins/*metabolism | en |
dc.subject | Cell Division | en |
dc.subject | Cyclin D1/metabolism | en |
dc.subject | Cyclin E/metabolism | en |
dc.subject | Cyclin-Dependent Kinase Inhibitor p21/metabolism | en |
dc.subject | Cyclin-Dependent Kinase Inhibitor p27/metabolism | en |
dc.subject | Disease-Free Survival | en |
dc.subject | Female | en |
dc.subject | Humans | en |
dc.subject | Immunohistochemistry | en |
dc.subject | Lymphatic Metastasis | en |
dc.subject | Male | en |
dc.subject | Middle Aged | en |
dc.subject | Neoplasm Invasiveness | en |
dc.subject | Neoplasm Staging | en |
dc.subject | Prognosis | en |
dc.subject | Stomach Neoplasms/mortality/*pathology | en |
dc.subject | Tumor Markers, Biological/*metabolism | en |
dc.title | Immunohistochemical analysis of cell cycle-related molecules in gastric carcinoma: prognostic significance, correlation with clinicopathological parameters, proliferation and apoptosis | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 이경희 | - |
dc.contributor.AlternativeAuthor | 이희은 | - |
dc.contributor.AlternativeAuthor | 조성진 | - |
dc.contributor.AlternativeAuthor | 조유진 | - |
dc.contributor.AlternativeAuthor | 이혜승 | - |
dc.contributor.AlternativeAuthor | 김지헌 | - |
dc.contributor.AlternativeAuthor | 남선영 | - |
dc.contributor.AlternativeAuthor | 장미수 | - |
dc.contributor.AlternativeAuthor | 김우호 | - |
dc.contributor.AlternativeAuthor | 이병란 | - |
dc.identifier.doi | 10.1159/000164221 | - |
- Appears in Collections:
- Files in This Item:
- There are no files associated with this item.
Item View & Download Count
Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.