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Maximal safe dose of I-131 after failure of standard fixed dose therapy in patients with differentiated thyroid carcinoma
DC Field | Value | Language |
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dc.contributor.author | Lee, Jong Jin | - |
dc.contributor.author | Chung, June-Key | - |
dc.contributor.author | Kim, Sung Eun | - |
dc.contributor.author | Kang, Won Jun | - |
dc.contributor.author | Park, Do Joon | - |
dc.contributor.author | Lee, Dong Soo | - |
dc.contributor.author | Cho, Bo Youn | - |
dc.contributor.author | Lee, Myung Chul | - |
dc.date.accessioned | 2010-06-25T06:44:43Z | - |
dc.date.available | 2010-06-25T06:44:43Z | - |
dc.date.issued | 2008-11-29 | - |
dc.identifier.citation | Ann Nucl Med. 2008;22(9):727-34 | en |
dc.identifier.issn | 0914-7187 (Print) | - |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=19039550 | - |
dc.identifier.uri | http://www.springerlink.com/content/u1w26q5217512224/fulltext.pdf | - |
dc.identifier.uri | https://hdl.handle.net/10371/67803 | - |
dc.description.abstract | OBJECTIVE: The maximal safe dose (MSD) on the basis of bone marrow irradiation levels allows the delivery of a large amount of I-131 to thyroid cancer tissue. The efficacy of MSD therapy in differentiated metastatic thyroid cancers that persisted after conventional fixed dose therapy is investigated. METHODS: Forty-seven differentiated thyroid carcinoma patients with non-responsive residual disease despite repetitive fixed dose I-131 therapy were enrolled in this study. Their postoperative pathologies were 43 papillary carcinomas and 4 follicular carcinomas. The MSD was calculated with the Memorial Sloan-Kettering Cancer Center protocol using serial blood samples. The MSDs were administered at intervals of 6 months. Treatment responses were evaluated using I-131 whole-body scans and serum thyroglobulin measurements. RESULTS: The mean calculated MSD was 12.5 +/- 2.1 GBq (339.6 +/- 57.5 mCi). Of the 46 patients, 7 (14.9%) showed complete remission, 15 (31.9%) partial remission, 19 (40.4%) stable disease, and 6 (12.8%) disease progression. Of the patients who showed complete or partial remission, 15 (65%) showed response after the first MSD session and 6 (26%) showed response after the second session. Twenty-nine patients (62%) experienced transient cytopenia after therapy, but three did not recover to the baseline level. CONCLUSIONS: The maximal safe dose provides an effective means of treatment in patients who failed to respond adequately to conventional fixed dose therapy. I-131 MSD therapy can be considered in patients who fail fixed dose therapy. | en |
dc.language.iso | en | en |
dc.publisher | Springer Verlag | en |
dc.subject | Adult | en |
dc.subject | Aged | en |
dc.subject | Dose Fractionation | en |
dc.subject | Dose-Response Relationship, Radiation | en |
dc.subject | Female | en |
dc.subject | Humans | en |
dc.subject | Iodine Radioisotopes/*administration & dosage/*toxicity | en |
dc.subject | Leukemia/*chemically induced/*prevention & control | en |
dc.subject | Male | en |
dc.subject | Middle Aged | en |
dc.subject | Radiopharmaceuticals/administration & dosage/toxicity | en |
dc.subject | Radiotherapy Dosage | en |
dc.subject | Thyroid Neoplasms/*radiotherapy | en |
dc.subject | Treatment Failure | en |
dc.subject | Treatment Outcome | en |
dc.subject | Young Adult | en |
dc.subject | Maximum Tolerated Dose | - |
dc.title | Maximal safe dose of I-131 after failure of standard fixed dose therapy in patients with differentiated thyroid carcinoma | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 이종진 | - |
dc.contributor.AlternativeAuthor | 정준기 | - |
dc.contributor.AlternativeAuthor | 김성은 | - |
dc.contributor.AlternativeAuthor | 강원준 | - |
dc.contributor.AlternativeAuthor | 박도준 | - |
dc.contributor.AlternativeAuthor | 이동수 | - |
dc.contributor.AlternativeAuthor | 조보연 | - |
dc.contributor.AlternativeAuthor | 이명철 | - |
dc.identifier.doi | 10.1007/s12149-007-0179-8 | - |
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