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A prospective evaluation of 18F-FDG and 11C-acetate PET/CT for detection of primary and metastatic hepatocellular carcinoma
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Park, Joong-Won | - |
dc.contributor.author | Kim, Ji Hoon | - |
dc.contributor.author | Kim, Seok Ki | - |
dc.contributor.author | Kang, Keon Wook | - |
dc.contributor.author | Park, Kyung Woo | - |
dc.contributor.author | Choi, Jun-Il | - |
dc.contributor.author | Lee, Woo Jin | - |
dc.contributor.author | Kim, Chang-Min | - |
dc.contributor.author | Nam, Byung Ho | - |
dc.date.accessioned | 2010-06-25T06:53:28Z | - |
dc.date.available | 2010-06-25T06:53:28Z | - |
dc.date.issued | 2008-11-11 | - |
dc.identifier.citation | J Nucl Med. 2008;49(12):1912-1921 | en |
dc.identifier.issn | 0161-5505 (Print) | - |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=18997056 | - |
dc.identifier.uri | http://jnm.snmjournals.org/cgi/reprint/49/12/1912.pdf | - |
dc.identifier.uri | https://hdl.handle.net/10371/67811 | - |
dc.description.abstract | Because (18)F-FDG PET has insufficient sensitivity for the detection of hepatocellular carcinoma (HCC), (11)C-acetate PET has been proposed as another technique for this use. We prospectively evaluated the value of PET/CT using these 2 tracers for the detection of primary and metastatic HCC. METHODS: One hundred twelve patients (99 with HCC, 13 with cholangiocellular carcinoma) underwent biopsy and (18)F-FDG and (11)C-acetate PET/CT. RESULTS: The overall sensitivities of (18)F-FDG, (11)C-acetate, and dual-tracer PET/CT in the detection of 110 lesions in 90 patients with primary HCC were 60.9%, 75.4%, and 82.7%, respectively. Elevated serum alpha-fetoprotein levels, an advanced tumor stage, portal vein tumor thrombosis, large tumors, and multiple tumors were significantly associated with positive (18)F-FDG PET/CT results. Uptake of (11)C-acetate was associated with large and multiple tumors. For (18)F-FDG, the sensitivities according to tumor size (1-2, 2-5, and >/=5 cm) were 27.2%, 47.8%, and 92.8%, respectively; for (11)C-acetate, these respective values were 31.8%, 78.2%, and 95.2%. (18)F-FDG was more sensitive in the detection of poorly differentiated HCC. Overall survival was lower in patients with (18)F-FDG PET/CT positive for all indexed lesions than in those with FDG negative or partially positive through the entire follow-up period. In analysis based on biopsied lesions, the sensitivity of (18)F-FDG PET/CT was 64.4% for primary HCC and 84.4% for (11)C-acetate PET/CT. The overall sensitivities of (18)F-FDG, (11)C-acetate, and dual-tracer PET/CT for 35 metastatic HCCs were 85.7%, 77.0%, and 85.7%, respectively. There was no significant difference in the sensitivity of tracers according to metastatic tumor size, location, or differentiation. CONCLUSION: The addition of (11)C-acetate to (18)F-FDG PET/CT increases the overall sensitivity for the detection of primary HCC but not for the detection of extrahepatic metastases. (18)F-FDG, (11)C-acetate, and dual-tracer PET/CT have a low sensitivity for the detection of small primary HCC, but (18)F-FDG PET/CT has a relatively high sensitivity for the detection of extrahepatic metastases of HCC. | en |
dc.description.sponsorship | This work was financially
supported by grant 0640390-1 from the National Cancer Center, Korea. | en |
dc.language.iso | en | en |
dc.publisher | The Society of Nuclear Medicine Inc | en |
dc.subject | Acetates/*diagnostic use | en |
dc.subject | Adult | en |
dc.subject | Carbon/*diagnostic use | en |
dc.subject | Female | en |
dc.subject | Fluorodeoxyglucose F18/*diagnostic use | en |
dc.subject | Humans | en |
dc.subject | Incidence | en |
dc.subject | Korea/epidemiology | en |
dc.subject | Liver Neoplasms/*diagnosis/*mortality | en |
dc.subject | Male | en |
dc.subject | Middle Aged | en |
dc.subject | Positron-Emission Tomography/*statistics & numerical data | en |
dc.subject | Prognosis | en |
dc.subject | Prospective Studies | en |
dc.subject | Radiopharmaceuticals/diagnostic use | en |
dc.subject | Reproducibility of Results | en |
dc.subject | Risk Assessment/methods | en |
dc.subject | Risk Factors | en |
dc.subject | Sensitivity and Specificity | en |
dc.subject | Subtraction Technique/statistics & numerical data | en |
dc.subject | Survival Analysis | en |
dc.subject | Survival Rate | en |
dc.subject | Tomography, X-Ray Computed/*statistics & numerical data | en |
dc.subject | Carcinoma, Hepatocellular/diagnosis/mortality/secondary | - |
dc.title | A prospective evaluation of 18F-FDG and 11C-acetate PET/CT for detection of primary and metastatic hepatocellular carcinoma | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 박중원 | - |
dc.contributor.AlternativeAuthor | 김지훈 | - |
dc.contributor.AlternativeAuthor | 김석기 | - |
dc.contributor.AlternativeAuthor | 강건욱 | - |
dc.contributor.AlternativeAuthor | 박경우 | - |
dc.contributor.AlternativeAuthor | 최전일 | - |
dc.contributor.AlternativeAuthor | 이우진 | - |
dc.contributor.AlternativeAuthor | 김창민 | - |
dc.contributor.AlternativeAuthor | 남병호 | - |
dc.identifier.doi | 10.2967/jnumed.108.055087 | - |
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