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A prospective evaluation of 18F-FDG and 11C-acetate PET/CT for detection of primary and metastatic hepatocellular carcinoma

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dc.contributor.authorPark, Joong-Won-
dc.contributor.authorKim, Ji Hoon-
dc.contributor.authorKim, Seok Ki-
dc.contributor.authorKang, Keon Wook-
dc.contributor.authorPark, Kyung Woo-
dc.contributor.authorChoi, Jun-Il-
dc.contributor.authorLee, Woo Jin-
dc.contributor.authorKim, Chang-Min-
dc.contributor.authorNam, Byung Ho-
dc.date.accessioned2010-06-25T06:53:28Z-
dc.date.available2010-06-25T06:53:28Z-
dc.date.issued2008-11-11-
dc.identifier.citationJ Nucl Med. 2008;49(12):1912-1921en
dc.identifier.issn0161-5505 (Print)-
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=18997056-
dc.identifier.urihttp://jnm.snmjournals.org/cgi/reprint/49/12/1912.pdf-
dc.identifier.urihttps://hdl.handle.net/10371/67811-
dc.description.abstractBecause (18)F-FDG PET has insufficient sensitivity for the detection of hepatocellular carcinoma (HCC), (11)C-acetate PET has been proposed as another technique for this use. We prospectively evaluated the value of PET/CT using these 2 tracers for the detection of primary and metastatic HCC. METHODS: One hundred twelve patients (99 with HCC, 13 with cholangiocellular carcinoma) underwent biopsy and (18)F-FDG and (11)C-acetate PET/CT. RESULTS: The overall sensitivities of (18)F-FDG, (11)C-acetate, and dual-tracer PET/CT in the detection of 110 lesions in 90 patients with primary HCC were 60.9%, 75.4%, and 82.7%, respectively. Elevated serum alpha-fetoprotein levels, an advanced tumor stage, portal vein tumor thrombosis, large tumors, and multiple tumors were significantly associated with positive (18)F-FDG PET/CT results. Uptake of (11)C-acetate was associated with large and multiple tumors. For (18)F-FDG, the sensitivities according to tumor size (1-2, 2-5, and >/=5 cm) were 27.2%, 47.8%, and 92.8%, respectively; for (11)C-acetate, these respective values were 31.8%, 78.2%, and 95.2%. (18)F-FDG was more sensitive in the detection of poorly differentiated HCC. Overall survival was lower in patients with (18)F-FDG PET/CT positive for all indexed lesions than in those with FDG negative or partially positive through the entire follow-up period. In analysis based on biopsied lesions, the sensitivity of (18)F-FDG PET/CT was 64.4% for primary HCC and 84.4% for (11)C-acetate PET/CT. The overall sensitivities of (18)F-FDG, (11)C-acetate, and dual-tracer PET/CT for 35 metastatic HCCs were 85.7%, 77.0%, and 85.7%, respectively. There was no significant difference in the sensitivity of tracers according to metastatic tumor size, location, or differentiation. CONCLUSION: The addition of (11)C-acetate to (18)F-FDG PET/CT increases the overall sensitivity for the detection of primary HCC but not for the detection of extrahepatic metastases. (18)F-FDG, (11)C-acetate, and dual-tracer PET/CT have a low sensitivity for the detection of small primary HCC, but (18)F-FDG PET/CT has a relatively high sensitivity for the detection of extrahepatic metastases of HCC.en
dc.description.sponsorshipThis work was financially
supported by grant 0640390-1 from the National Cancer
Center, Korea.
en
dc.language.isoenen
dc.publisherThe Society of Nuclear Medicine Incen
dc.subjectAcetates/*diagnostic useen
dc.subjectAdulten
dc.subjectCarbon/*diagnostic useen
dc.subject*Carcinoma, Hepatocellular/diagnosis/mortality/secondaryen
dc.subjectFemaleen
dc.subjectFluorodeoxyglucose F18/*diagnostic useen
dc.subjectHumansen
dc.subjectIncidenceen
dc.subjectKorea/epidemiologyen
dc.subjectLiver Neoplasms/*diagnosis/*mortalityen
dc.subjectMaleen
dc.subjectMiddle Ageden
dc.subjectPositron-Emission Tomography/*statistics & numerical dataen
dc.subjectPrognosisen
dc.subjectProspective Studiesen
dc.subjectRadiopharmaceuticals/diagnostic useen
dc.subjectReproducibility of Resultsen
dc.subjectRisk Assessment/methodsen
dc.subjectRisk Factorsen
dc.subjectSensitivity and Specificityen
dc.subjectSubtraction Technique/statistics & numerical dataen
dc.subjectSurvival Analysisen
dc.subjectSurvival Rateen
dc.subjectTomography, X-Ray Computed/*statistics & numerical dataen
dc.titleA prospective evaluation of 18F-FDG and 11C-acetate PET/CT for detection of primary and metastatic hepatocellular carcinomaen
dc.typeArticleen
dc.contributor.AlternativeAuthor박중원-
dc.contributor.AlternativeAuthor김지훈-
dc.contributor.AlternativeAuthor김석기-
dc.contributor.AlternativeAuthor강건욱-
dc.contributor.AlternativeAuthor박경우-
dc.contributor.AlternativeAuthor최전일-
dc.contributor.AlternativeAuthor이우진-
dc.contributor.AlternativeAuthor김창민-
dc.contributor.AlternativeAuthor남병호-
dc.identifier.doi10.2967/jnumed.108.055087-
Appears in Collections:
College of Medicine/School of Medicine (의과대학/대학원)Nuclear Medicine (핵의학전공)Journal Papers (저널논문_핵의학전공)
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