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Hyperghrelinemia does not accelerate gastric emptying in Prader-Willi syndrome patients
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Choe, Yon Ho | - |
dc.contributor.author | Jin, Dong-Kyu | - |
dc.contributor.author | Kim, Sang Eun | - |
dc.contributor.author | Song, Sang Yong | - |
dc.contributor.author | Paik, Kyung Hoon | - |
dc.contributor.author | Park, Hwa Young | - |
dc.contributor.author | Oh, Yoo Joung | - |
dc.contributor.author | Kim, An Hee | - |
dc.contributor.author | Kim, Jung Sim | - |
dc.contributor.author | Kim, Chi Wha | - |
dc.contributor.author | Chu, Su-Hyun | - |
dc.contributor.author | Kwon, Eun Kyung | - |
dc.contributor.author | Lee, Kyung Han | - |
dc.date.accessioned | 2010-06-25T07:00:31Z | - |
dc.date.available | 2010-06-25T07:00:31Z | - |
dc.date.issued | 2005-01-20 | - |
dc.identifier.citation | J Clin Endocrinol Metab. 90(6):3367-3370 | en |
dc.identifier.issn | 0021-972X (Print) | - |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=15657368 | - |
dc.identifier.uri | https://hdl.handle.net/10371/67817 | - |
dc.description.abstract | Prader-Willi syndrome (PWS) is the most common form of syndromic obesity associated with hyperphagia. Because ghrelin stimulates gastric motility in rodents, and PWS patients have 3- to 4-fold higher fasting plasma ghrelin concentrations than normal subjects, we hypothesized that hyperphagia associated with PWS may be partly explained by rapid gastric emptying due to the increased gastric motility caused by ghrelin. We determined gastric emptying times (GETs) and measured ghrelin levels in 11 PWS children and 11 age-, sex-, and body mass index-matched controls using a standard meal containing [(99m)Tc]diaminetriaminepentacetate. Median plasma ghrelin levels before (precibum) and after the GET study were higher in PWS patients than in controls (P = 0.004 and P = 0.001, respectively). Median percent gastric retentions at 90 min after the standard meal were 57.1% (range, 34.0-83.2%) in PWS patients and 40.2% (range, 27.2-60.2%) in controls (P = 0.03). In particular, precibum ghrelin concentrations were not significantly correlated with the rate of gastric emptying in PWS patients (P = 0.153; r = 0.461) or controls (P = 0.911; r = 0.048). Our results show that gastric emptying in PWS is reduced despite higher ghrelin levels, and that the voracious appetite associated with PWS is related to another mechanism. | en |
dc.language.iso | en | en |
dc.publisher | Endocrine Society | en |
dc.subject | Adolescent | en |
dc.subject | Body Height | en |
dc.subject | Body Weight | en |
dc.subject | Child | en |
dc.subject | Female | en |
dc.subject | Gastric Emptying/*physiology | en |
dc.subject | Ghrelin | en |
dc.subject | Humans | en |
dc.subject | Male | en |
dc.subject | Peptide Hormones/*blood | en |
dc.subject | Prader-Willi Syndrome/*blood/*physiopathology | en |
dc.subject | Reference Values | en |
dc.title | Hyperghrelinemia does not accelerate gastric emptying in Prader-Willi syndrome patients | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 최연호 | - |
dc.contributor.AlternativeAuthor | 진동규 | - |
dc.contributor.AlternativeAuthor | 김상은 | - |
dc.contributor.AlternativeAuthor | 송상용 | - |
dc.contributor.AlternativeAuthor | 백경훈 | - |
dc.contributor.AlternativeAuthor | 박화영 | - |
dc.contributor.AlternativeAuthor | 오유정 | - |
dc.contributor.AlternativeAuthor | 김안희 | - |
dc.contributor.AlternativeAuthor | 김정심 | - |
dc.contributor.AlternativeAuthor | 김지화 | - |
dc.contributor.AlternativeAuthor | 추수현 | - |
dc.contributor.AlternativeAuthor | 권은경 | - |
dc.contributor.AlternativeAuthor | 이경한 | - |
dc.identifier.doi | 10.1210/jc.2004-1651 | - |
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