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Hyperghrelinemia does not accelerate gastric emptying in Prader-Willi syndrome patients

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dc.contributor.authorChoe, Yon Ho-
dc.contributor.authorJin, Dong-Kyu-
dc.contributor.authorKim, Sang Eun-
dc.contributor.authorSong, Sang Yong-
dc.contributor.authorPaik, Kyung Hoon-
dc.contributor.authorPark, Hwa Young-
dc.contributor.authorOh, Yoo Joung-
dc.contributor.authorKim, An Hee-
dc.contributor.authorKim, Jung Sim-
dc.contributor.authorKim, Chi Wha-
dc.contributor.authorChu, Su-Hyun-
dc.contributor.authorKwon, Eun Kyung-
dc.contributor.authorLee, Kyung Han-
dc.date.accessioned2010-06-25T07:00:31Z-
dc.date.available2010-06-25T07:00:31Z-
dc.date.issued2005-01-20-
dc.identifier.citationJ Clin Endocrinol Metab. 90(6):3367-3370en
dc.identifier.issn0021-972X (Print)-
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=15657368-
dc.identifier.urihttps://hdl.handle.net/10371/67817-
dc.description.abstractPrader-Willi syndrome (PWS) is the most common form of syndromic obesity associated with hyperphagia. Because ghrelin stimulates gastric motility in rodents, and PWS patients have 3- to 4-fold higher fasting plasma ghrelin concentrations than normal subjects, we hypothesized that hyperphagia associated with PWS may be partly explained by rapid gastric emptying due to the increased gastric motility caused by ghrelin. We determined gastric emptying times (GETs) and measured ghrelin levels in 11 PWS children and 11 age-, sex-, and body mass index-matched controls using a standard meal containing [(99m)Tc]diaminetriaminepentacetate. Median plasma ghrelin levels before (precibum) and after the GET study were higher in PWS patients than in controls (P = 0.004 and P = 0.001, respectively). Median percent gastric retentions at 90 min after the standard meal were 57.1% (range, 34.0-83.2%) in PWS patients and 40.2% (range, 27.2-60.2%) in controls (P = 0.03). In particular, precibum ghrelin concentrations were not significantly correlated with the rate of gastric emptying in PWS patients (P = 0.153; r = 0.461) or controls (P = 0.911; r = 0.048). Our results show that gastric emptying in PWS is reduced despite higher ghrelin levels, and that the voracious appetite associated with PWS is related to another mechanism.en
dc.language.isoenen
dc.publisherEndocrine Societyen
dc.subjectAdolescenten
dc.subjectBody Heighten
dc.subjectBody Weighten
dc.subjectChilden
dc.subjectFemaleen
dc.subjectGastric Emptying/*physiologyen
dc.subjectGhrelinen
dc.subjectHumansen
dc.subjectMaleen
dc.subjectPeptide Hormones/*blooden
dc.subjectPrader-Willi Syndrome/*blood/*physiopathologyen
dc.subjectReference Valuesen
dc.titleHyperghrelinemia does not accelerate gastric emptying in Prader-Willi syndrome patientsen
dc.typeArticleen
dc.contributor.AlternativeAuthor최연호-
dc.contributor.AlternativeAuthor진동규-
dc.contributor.AlternativeAuthor김상은-
dc.contributor.AlternativeAuthor송상용-
dc.contributor.AlternativeAuthor백경훈-
dc.contributor.AlternativeAuthor박화영-
dc.contributor.AlternativeAuthor오유정-
dc.contributor.AlternativeAuthor김안희-
dc.contributor.AlternativeAuthor김정심-
dc.contributor.AlternativeAuthor김지화-
dc.contributor.AlternativeAuthor추수현-
dc.contributor.AlternativeAuthor권은경-
dc.contributor.AlternativeAuthor이경한-
dc.identifier.doi10.1210/jc.2004-1651-
Appears in Collections:
College of Medicine/School of Medicine (의과대학/대학원)Nuclear Medicine (핵의학전공)Journal Papers (저널논문_핵의학전공)
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