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Serum measurements of testosterone, insulin-like growth factor 1, and insulin-like growth factor binding protein-3 in the diagnosis of prostate cancer among Korean men

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dc.contributor.authorHong, Sung Kyu-
dc.contributor.authorHan, Byung Kyu-
dc.contributor.authorJeong, Jae Seung-
dc.contributor.authorJeong, Seong Jin-
dc.contributor.authorMoon, Ki Hyuk-
dc.contributor.authorByun, Seok Soo-
dc.contributor.authorLee, Sang Eun-
dc.date.accessioned2010-06-28T23:01:00Z-
dc.date.available2010-06-28T23:01:00Z-
dc.date.issued2007-12-22-
dc.identifier.citationAsian J Androl. 2008; 10(2): 207-213en
dc.identifier.issn1008-682X (Print)-
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=18097534-
dc.identifier.urihttp://www.nature.com/aja/journal/v10/n2/pdf/aja2008226a.pdf-
dc.identifier.urihttp://hdl.handle.net/10371/67942-
dc.description.abstractAIM: To investigate the relationships of serum testosterone, insulin-like growth factor (IGF)-1 and IGF-binding protein (IGFBP)-3 levels with prostate cancer risk and also with known prognostic parameters of prostate cancer in Korean men who received radical retropubic prostatectomy (RRP) for clinically-localized prostate cancer. METHODS: Serum levels of total testosterone, free testosterone, IGF-1 and IGFBP-3 were determined in 592 patients who subsequently received prostate biopsy. Results were compared between patients who eventually received RRP for prostate cancer (n=159) and those who were not diagnosed with prostate cancer from biopsy (control group, n=433). Among the prostate cancer only patients, serum hormonal levels obtained were analyzed in relation to serum prostate specific antigen (PSA), pathological T stage and pathological Gleason score. RESULTS: Prostate cancer patients and the control group demonstrated no significant differences regarding serum levels of total testosterone, free testosterone, IGF-1 and IGFBP-3 across the different age groups. Among the cancer only patients, no significant associations were observed for serum levels of total testosterone, free testosterone, IGF-1 and IGFBP-3 levels with pathological T stage, pathological Gleason score and preoperative PSA. CONCLUSION: Our data indicate that simple quantifications of serum testosterone and IGF-1 along with IGFBP-3 levels might not provide useful clinical information in the diagnosis of clinically localized prostate cancer in Korean men. Also, our results suggest that serum levels of testosterone, IGF-1 and IGFBP-3 might not be significantly associated with known prognostic factors of clinically localized prostate cancer in Korean men.en
dc.language.isoenen
dc.publisherWiley-Blackwellen
dc.subjectAgeden
dc.subjectBiopsy, Needleen
dc.subjectHumansen
dc.subjectInsulin-Like Growth Factor Binding Proteins/*blooden
dc.subjectInsulin-Like Growth Factor I/*analysisen
dc.subjectKoreaen
dc.subjectMaleen
dc.subjectMiddle Ageden
dc.subjectPrognosisen
dc.subjectProstatic Neoplasms/*blood/pathologyen
dc.subjectTestosterone/*blooden
dc.subjectTumor Markers, Biological/*blooden
dc.titleSerum measurements of testosterone, insulin-like growth factor 1, and insulin-like growth factor binding protein-3 in the diagnosis of prostate cancer among Korean menen
dc.typeArticleen
dc.contributor.AlternativeAuthor홍성규-
dc.contributor.AlternativeAuthor한병규-
dc.contributor.AlternativeAuthor정재승-
dc.contributor.AlternativeAuthor정성진-
dc.contributor.AlternativeAuthor문기혁-
dc.contributor.AlternativeAuthor변석수-
dc.contributor.AlternativeAuthor이상은-
dc.identifier.doi10.1111/j.1745-7262.2008.00296.x-
Appears in Collections:
College of Medicine/School of Medicine (의과대학/대학원)Urology (비뇨기과학전공)Journal Papers (저널논문_비뇨기과학전공)
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