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Serum measurements of testosterone, insulin-like growth factor 1, and insulin-like growth factor binding protein-3 in the diagnosis of prostate cancer among Korean men
DC Field | Value | Language |
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dc.contributor.author | Hong, Sung Kyu | - |
dc.contributor.author | Han, Byung Kyu | - |
dc.contributor.author | Jeong, Jae Seung | - |
dc.contributor.author | Jeong, Seong Jin | - |
dc.contributor.author | Moon, Ki Hyuk | - |
dc.contributor.author | Byun, Seok Soo | - |
dc.contributor.author | Lee, Sang Eun | - |
dc.date.accessioned | 2010-06-28T23:01:00Z | - |
dc.date.available | 2010-06-28T23:01:00Z | - |
dc.date.issued | 2007-12-22 | - |
dc.identifier.citation | Asian J Androl. 2008; 10(2): 207-213 | en |
dc.identifier.issn | 1008-682X (Print) | - |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=18097534 | - |
dc.identifier.uri | http://www.nature.com/aja/journal/v10/n2/pdf/aja2008226a.pdf | - |
dc.identifier.uri | https://hdl.handle.net/10371/67942 | - |
dc.description.abstract | AIM: To investigate the relationships of serum testosterone, insulin-like growth factor (IGF)-1 and IGF-binding protein (IGFBP)-3 levels with prostate cancer risk and also with known prognostic parameters of prostate cancer in Korean men who received radical retropubic prostatectomy (RRP) for clinically-localized prostate cancer. METHODS: Serum levels of total testosterone, free testosterone, IGF-1 and IGFBP-3 were determined in 592 patients who subsequently received prostate biopsy. Results were compared between patients who eventually received RRP for prostate cancer (n=159) and those who were not diagnosed with prostate cancer from biopsy (control group, n=433). Among the prostate cancer only patients, serum hormonal levels obtained were analyzed in relation to serum prostate specific antigen (PSA), pathological T stage and pathological Gleason score. RESULTS: Prostate cancer patients and the control group demonstrated no significant differences regarding serum levels of total testosterone, free testosterone, IGF-1 and IGFBP-3 across the different age groups. Among the cancer only patients, no significant associations were observed for serum levels of total testosterone, free testosterone, IGF-1 and IGFBP-3 levels with pathological T stage, pathological Gleason score and preoperative PSA. CONCLUSION: Our data indicate that simple quantifications of serum testosterone and IGF-1 along with IGFBP-3 levels might not provide useful clinical information in the diagnosis of clinically localized prostate cancer in Korean men. Also, our results suggest that serum levels of testosterone, IGF-1 and IGFBP-3 might not be significantly associated with known prognostic factors of clinically localized prostate cancer in Korean men. | en |
dc.language.iso | en | en |
dc.publisher | Wiley-Blackwell | en |
dc.subject | Aged | en |
dc.subject | Biopsy, Needle | en |
dc.subject | Humans | en |
dc.subject | Insulin-Like Growth Factor Binding Proteins/*blood | en |
dc.subject | Insulin-Like Growth Factor I/*analysis | en |
dc.subject | Korea | en |
dc.subject | Male | en |
dc.subject | Middle Aged | en |
dc.subject | Prognosis | en |
dc.subject | Prostatic Neoplasms/*blood/pathology | en |
dc.subject | Testosterone/*blood | en |
dc.subject | Tumor Markers, Biological/*blood | en |
dc.title | Serum measurements of testosterone, insulin-like growth factor 1, and insulin-like growth factor binding protein-3 in the diagnosis of prostate cancer among Korean men | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 홍성규 | - |
dc.contributor.AlternativeAuthor | 한병규 | - |
dc.contributor.AlternativeAuthor | 정재승 | - |
dc.contributor.AlternativeAuthor | 정성진 | - |
dc.contributor.AlternativeAuthor | 문기혁 | - |
dc.contributor.AlternativeAuthor | 변석수 | - |
dc.contributor.AlternativeAuthor | 이상은 | - |
dc.identifier.doi | 10.1111/j.1745-7262.2008.00296.x | - |
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