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Oxidized and reduced mannan mediated MUC1 DNA immunization induce effective anti-tumor responses
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Tang, Choon Kit | - |
dc.contributor.author | Sheng, Kuo-Ching | - |
dc.contributor.author | Pouniotis, Dodie | - |
dc.contributor.author | Esparon, Sandra | - |
dc.contributor.author | Son, Hye-Youn | - |
dc.contributor.author | Kim, Chul-Woo | - |
dc.contributor.author | Pietersz, Geoffrey A | - |
dc.contributor.author | Apostolopoulos, Vasso | - |
dc.date.accessioned | 2010-06-28T23:13:30Z | - |
dc.date.available | 2010-06-28T23:13:30Z | - |
dc.date.issued | 2008-06-14 | - |
dc.identifier.citation | Vaccine. 2008;26(31):3827-3834 | en |
dc.identifier.issn | 0264-410X (Print) | - |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=18550230 | - |
dc.identifier.uri | http://www.sciencedirect.com/science?_ob=MImg&_imagekey=B6TD4-4SK09TR-3-F&_cdi=5188&_user=168665&_orig=search&_coverDate=07%2F23%2F2008&_sk=999739968&view=c&wchp=dGLbVlz-zSkWz&md5=b14d28044606ac69178614cd48a1de90&ie=/sdarticle.pdf | - |
dc.identifier.uri | https://hdl.handle.net/10371/67951 | - |
dc.description.abstract | DNA immunization is an attractive form of vaccination, which has shown promising results only in small animal models. There is a need to develop efficient gene delivery systems. We previously demonstrated that oxidized (OM) and reduced mannan (RM) complexed to ovalbumin DNA via poly-l-lysine (PLL), were able to generate potent immune responses in mice. Herein, we further investigated the suitability of OMPLL and RMPLL as carriers for mucin 1 (MUC1) DNA vaccination for cancer immunotherapy. Studies presented here showed that immune responses in C57BL/6 mice induced by OMPLL-MUC1 DNA and RMPLL-MUC1 DNA immunization were more immunogenic compared to MUC1 DNA alone. Moreover, tumor protection was evident at a dose as low as 0.5 microg. In addition, strong T cell responses were induced in HLA-A2 transgenic and human MUC1 transgenic mice. These results demonstrate the potential of OM and RM as efficient non-viral gene delivery carriers for DNA vaccines for use in cancer immunotherapy. | en |
dc.language.iso | en | en |
dc.publisher | Elsevier | en |
dc.subject | Animals | en |
dc.subject | Cancer Vaccines/*immunology | en |
dc.subject | Cytokines/secretion | en |
dc.subject | HLA-A2 Antigen/genetics | en |
dc.subject | Humans | en |
dc.subject | Mannans/*immunology/*metabolism | en |
dc.subject | Mice | en |
dc.subject | Mice, Inbred C57BL | en |
dc.subject | Mice, Transgenic | en |
dc.subject | Mucin-1/genetics/*immunology | en |
dc.subject | Neoplasms/pathology/prevention & control | en |
dc.subject | Oxidation-Reduction | en |
dc.subject | Survival Analysis | en |
dc.subject | Vaccines, DNA/*immunology/metabolism | en |
dc.title | Oxidized and reduced mannan mediated MUC1 DNA immunization induce effective anti-tumor responses | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 손혜윤 | - |
dc.contributor.AlternativeAuthor | 김철우 | - |
dc.identifier.doi | 10.1016/j.vaccine.2008.05.008 | - |
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