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Oxidized and reduced mannan mediated MUC1 DNA immunization induce effective anti-tumor responses

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dc.contributor.authorTang, Choon Kit-
dc.contributor.authorSheng, Kuo-Ching-
dc.contributor.authorPouniotis, Dodie-
dc.contributor.authorEsparon, Sandra-
dc.contributor.authorSon, Hye-Youn-
dc.contributor.authorKim, Chul-Woo-
dc.contributor.authorPietersz, Geoffrey A-
dc.contributor.authorApostolopoulos, Vasso-
dc.date.accessioned2010-06-28T23:13:30Z-
dc.date.available2010-06-28T23:13:30Z-
dc.date.issued2008-06-14-
dc.identifier.citationVaccine. 2008;26(31):3827-3834en
dc.identifier.issn0264-410X (Print)-
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=18550230-
dc.identifier.urihttp://www.sciencedirect.com/science?_ob=MImg&_imagekey=B6TD4-4SK09TR-3-F&_cdi=5188&_user=168665&_orig=search&_coverDate=07%2F23%2F2008&_sk=999739968&view=c&wchp=dGLbVlz-zSkWz&md5=b14d28044606ac69178614cd48a1de90&ie=/sdarticle.pdf-
dc.identifier.urihttps://hdl.handle.net/10371/67951-
dc.description.abstractDNA immunization is an attractive form of vaccination, which has shown promising results only in small animal models. There is a need to develop efficient gene delivery systems. We previously demonstrated that oxidized (OM) and reduced mannan (RM) complexed to ovalbumin DNA via poly-l-lysine (PLL), were able to generate potent immune responses in mice. Herein, we further investigated the suitability of OMPLL and RMPLL as carriers for mucin 1 (MUC1) DNA vaccination for cancer immunotherapy. Studies presented here showed that immune responses in C57BL/6 mice induced by OMPLL-MUC1 DNA and RMPLL-MUC1 DNA immunization were more immunogenic compared to MUC1 DNA alone. Moreover, tumor protection was evident at a dose as low as 0.5 microg. In addition, strong T cell responses were induced in HLA-A2 transgenic and human MUC1 transgenic mice. These results demonstrate the potential of OM and RM as efficient non-viral gene delivery carriers for DNA vaccines for use in cancer immunotherapy.en
dc.language.isoenen
dc.publisherElsevieren
dc.subjectAnimalsen
dc.subjectCancer Vaccines/*immunologyen
dc.subjectCytokines/secretionen
dc.subjectHLA-A2 Antigen/geneticsen
dc.subjectHumansen
dc.subjectMannans/*immunology/*metabolismen
dc.subjectMiceen
dc.subjectMice, Inbred C57BLen
dc.subjectMice, Transgenicen
dc.subjectMucin-1/genetics/*immunologyen
dc.subjectNeoplasms/pathology/prevention & controlen
dc.subjectOxidation-Reductionen
dc.subjectSurvival Analysisen
dc.subjectVaccines, DNA/*immunology/metabolismen
dc.titleOxidized and reduced mannan mediated MUC1 DNA immunization induce effective anti-tumor responsesen
dc.typeArticleen
dc.contributor.AlternativeAuthor손혜윤-
dc.contributor.AlternativeAuthor김철우-
dc.identifier.doi10.1016/j.vaccine.2008.05.008-
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