S-Space College of Medicine/School of Medicine (의과대학/대학원) Pediatrics (소아과학전공) Journal Papers (저널논문_소아과학전공)
Mycoplasma pneumoniae in Korean children: the epidemiology of pneumonia over an 18-year period
- Eun, Byung Wook; Kim, Nam Hee; Choi, Eun Hwa; Lee, Hoan Jong
- Issue Date
- J Infect. 2008;56(5):326-331
- Age Distribution; Antibodies, Bacterial/blood; Child; Child, Preschool; *Disease Outbreaks; Female; Hospitals, Pediatric; Hospitals, University; Humans; Infant; Infant, Newborn; Korea/epidemiology; Male; Mycoplasma pneumoniae/*immunology; Pneumonia, Mycoplasma/*epidemiology/microbiology; Time Factors
- OBJECTIVES: Mycoplasma pneumoniae (MP) is a major cause of community-acquired pneumonia in children. The aim of this study was to investigate the long-term epidemiology of MP pneumonia in Korean children. METHODS: A retrospective analysis of a database of 2405 patients with pneumonia at the Seoul National University Children's Hospital between 1986 and 2004 was performed. Serologic diagnosis for MP infection was made based on a 4-fold rise or single titers >/=1:640, which were measured by an indirect agglutination test. RESULTS: MP pneumonia was diagnosed in 568 patients over 18 years. The mean age was 5.7 years. Children younger than 5 years of age accounted for 44% of the cases. Six outbreaks were observed at intervals of 3-4 years. The earlier epidemics up until 1996 peaked in the summer, while the later epidemics peaked in the fall or early winter. Children <5 years old were more commonly affected during large epidemics compared to endemic periods. The geometric mean antibody titers were maintained >/=1:320 up to 7 months after the onset of illness. CONCLUSIONS: The results of this study revealed community outbreaks of MP pneumonia at 3-4-year intervals among Korean children. A significant proportion of young Korean children were affected by MP pneumonia, especially during large epidemics.
- 1532-2742 (Electronic)
- Files in This Item: There are no files associated with this item.