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Mycoplasma pneumoniae in Korean children: the epidemiology of pneumonia over an 18-year period
Cited 53 time in
Web of Science
Cited 57 time in Scopus
- Authors
- Issue Date
- 2008-04-19
- Publisher
- Elsevier
- Citation
- J Infect. 2008;56(5):326-331
- Keywords
- Age Distribution ; Antibodies, Bacterial/blood ; Child ; Child, Preschool ; Female ; Hospitals, Pediatric ; Hospitals, University ; Humans ; Infant ; Infant, Newborn ; Korea/epidemiology ; Male ; Mycoplasma pneumoniae/*immunology ; Pneumonia, Mycoplasma/*epidemiology/microbiology ; Time Factors ; Disease Outbreaks
- Abstract
- OBJECTIVES: Mycoplasma pneumoniae (MP) is a major cause of community-acquired pneumonia in children. The aim of this study was to investigate the long-term epidemiology of MP pneumonia in Korean children. METHODS: A retrospective analysis of a database of 2405 patients with pneumonia at the Seoul National University Children's Hospital between 1986 and 2004 was performed. Serologic diagnosis for MP infection was made based on a 4-fold rise or single titers >/=1:640, which were measured by an indirect agglutination test. RESULTS: MP pneumonia was diagnosed in 568 patients over 18 years. The mean age was 5.7 years. Children younger than 5 years of age accounted for 44% of the cases. Six outbreaks were observed at intervals of 3-4 years. The earlier epidemics up until 1996 peaked in the summer, while the later epidemics peaked in the fall or early winter. Children <5 years old were more commonly affected during large epidemics compared to endemic periods. The geometric mean antibody titers were maintained >/=1:320 up to 7 months after the onset of illness. CONCLUSIONS: The results of this study revealed community outbreaks of MP pneumonia at 3-4-year intervals among Korean children. A significant proportion of young Korean children were affected by MP pneumonia, especially during large epidemics.
- ISSN
- 1532-2742 (Electronic)
- Language
- English
- URI
- http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=18420275
http://www.sciencedirect.com/science?_ob=MImg&_imagekey=B6WJT-4S97J6W-1-7&_cdi=6887&_user=168665&_orig=search&_coverDate=05%2F31%2F2008&_sk=999439994&view=c&wchp=dGLzVtz-zSkWA&md5=139904a4b53afa941aaffa10d9c3baec&ie=/sdarticle.pdf
https://hdl.handle.net/10371/68128
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