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Degradation of transglutaminase 2 by calcium-mediated ubiquitination responding to high oxidative stress
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Jeong, Eui Man | - |
dc.contributor.author | Kim, Chai-Wan | - |
dc.contributor.author | Cho, Sung-Yup | - |
dc.contributor.author | Jang, Gi-Yong | - |
dc.contributor.author | Shin, Dong-Myung | - |
dc.contributor.author | Jeon, Ju-Hong | - |
dc.contributor.author | Kim, In-Gyu | - |
dc.date.accessioned | 2010-07-01T05:42:54Z | - |
dc.date.available | 2010-07-01T05:42:54Z | - |
dc.date.issued | 2009-02-03 | - |
dc.identifier.citation | FEBS Lett. 583(4), 648-654 | en |
dc.identifier.issn | 1873-3468 (Electronic) | - |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=19183553 | - |
dc.identifier.uri | http://www.sciencedirect.com/science?_ob=MImg&_imagekey=B6T36-4VGDKWR-2-F&_cdi=4938&_user=168665&_orig=search&_coverDate=02%2F18%2F2009&_sk=994169995&view=c&wchp=dGLzVtz-zSkWA&md5=6fff65f9511699162a762b3c2fa20ce3&ie=/sdarticle.pdf | - |
dc.identifier.uri | https://hdl.handle.net/10371/68135 | - |
dc.description.abstract | Transglutaminase 2 (TG2) is a calcium-dependent enzyme that catalyzes the transamidation reaction. There is conflicting evidence on the role of TG2 in apoptosis. In this report, we show that TG2 increases in response to low level of oxidative stress, whereas TG2 diminishes under high stress conditions. Monitoring TG2 expression, activity and calcium concentration in cells treated with A23187 revealed that the initial rise of calcium activates TG2 but subsequent calcium-overload induces the degradation of TG2 via calcium-mediated polyubiquitination. These results indicate that the role of TG2 in apoptosis depends on the level of calcium influx triggered by oxidative stress. | en |
dc.description.sponsorship | This work was supported by the grants from
Korea Science and Engineering Foundation (R11-2002-097- 09005-0 and R01-2005-000-10364-0) and also by the Research Program for New Drug Target Discovery (M10748000296- 07N4800-29610). | en |
dc.language.iso | en | en |
dc.publisher | Elsevier | en |
dc.subject | Adenoviridae/genetics | en |
dc.subject | Anti-Bacterial Agents/pharmacology | en |
dc.subject | Apoptosis | en |
dc.subject | Calcimycin/pharmacology | en |
dc.subject | Calcium/*metabolism | en |
dc.subject | Cell Death | en |
dc.subject | Cell Line | en |
dc.subject | Culture Media, Serum-Free | en |
dc.subject | Dose-Response Relationship, Drug | en |
dc.subject | Enzyme Inhibitors/pharmacology | en |
dc.subject | GTP-Binding Proteins/*metabolism | en |
dc.subject | Hela Cells | en |
dc.subject | Humans | en |
dc.subject | Kidney/cytology | en |
dc.subject | Leupeptins/pharmacology | en |
dc.subject | Time Factors | en |
dc.subject | Transglutaminases/*metabolism | en |
dc.subject | Ubiquitination | en |
dc.subject | Oxidative Stress | - |
dc.title | Degradation of transglutaminase 2 by calcium-mediated ubiquitination responding to high oxidative stress | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 정의만 | - |
dc.contributor.AlternativeAuthor | 김채완 | - |
dc.contributor.AlternativeAuthor | 조성엽 | - |
dc.contributor.AlternativeAuthor | 장기용 | - |
dc.contributor.AlternativeAuthor | 신동명 | - |
dc.contributor.AlternativeAuthor | 전주홍 | - |
dc.contributor.AlternativeAuthor | 김인규 | - |
dc.identifier.doi | 10.1016/j.febslet.2009.01.032 | - |
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