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Long-lasting enhancement in the intrinsic excitability of deep dorsal horn neurons

Cited 7 time in Web of Science Cited 6 time in Scopus
Authors
Kim, Dong Kwan; Kwak, Jiyeon; Kim, Sang Jeong; Kim, Jun
Issue Date
2008-05-13
Publisher
Elsevier
Citation
Pain. 2008;139(1):181-189
Keywords
Action Potentials/physiologyAnimalsLong-Term Potentiation/*physiologyNeuronal Plasticity/physiologyPosterior Horn Cells/*physiologyRats
Abstract
Intrinsic excitability (IE) can be defined as an output of action potentials from a given input signal. Changes to the IE of a neuron are an important aspect of the cellular plasticity that underlies learning and memory process. In this study, long-term plastic change in IE of deep dorsal horn neurons (DHNs) was investigated. Associative spike pairing stimulation (PS) induced a long-lasting increase in IE. Buffering intracellular calcium with BAPTA (10mM) prevented the induction of a long-lasting increase in IE. PS failed to induce a long-lasting increase in IE in the presence of either D-APV (50 microM) or cadmium chloride (100 microM). Apamin (100 nM) partially blocked the induction of a long-lasting increase in IE. This intrinsic plasticity requires a rise in postsynaptic Ca(2+) and NMDA receptor activation during the induction period, and this process might be mediated by the down-regulation of small-conductance calcium-dependent potassium (SK) channels. In deep DHNs, PS induced excitatory postsynaptic potential (EPSP)-spike (E-S) potentiation, which increases the firing probability and the number of spikes, by consistent dorsal rootlet stimulation. Under bath application of bicuculline (10 microM) and strychnine (1 microM), PS induced E-S potentiation and long-lasting increases in IE. These results suggest that an increase in IE might underlie E-S potentiation, while a reduction in inhibitory transmission does not contribute to E-S potentiation and long-lasting increases in IE. We conclude that PS enhances the IE of deep DHNs, which may play an important role in spinal processing of nociceptive information.
ISSN
1872-6623 (Electronic)
Language
English
URI
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=18472218

http://www.sciencedirect.com/science?_ob=MImg&_imagekey=B6T0K-4SG556Y-2-S&_cdi=4865&_user=168665&_orig=search&_coverDate=09%2F30%2F2008&_sk=998609998&view=c&wchp=dGLbVlb-zSkWA&md5=93481025ce0543a94a96e797cc4fd674&ie=/sdarticle.pdf

https://hdl.handle.net/10371/68151
DOI
https://doi.org/10.1016/j.pain.2008.03.025
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College of Medicine/School of Medicine (의과대학/대학원)Dept. of Physiology (생리학교실)Journal Papers (저널논문_생리학교실)
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