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Staged diabetes management according to individual patient insulin resistance and beta-cell function ameliorates glycaemic control in type 2 diabetes mellitus
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Choi, Sung Hee | - |
dc.contributor.author | Hur, Kyu Yeon | - |
dc.contributor.author | Kim, Dae Jung | - |
dc.contributor.author | Ahn, Chul Woo | - |
dc.contributor.author | Kang, Eun Seok | - |
dc.contributor.author | Cha, Bong Soo | - |
dc.contributor.author | Lim, Sung Kil | - |
dc.contributor.author | Huh, Kap Bum | - |
dc.contributor.author | Lee, Hyun Chul | - |
dc.date.accessioned | 2010-07-01T23:19:09Z | - |
dc.date.available | 2010-07-01T23:19:09Z | - |
dc.date.issued | 2008-02-06 | - |
dc.identifier.citation | Clin Endocrinol (Oxf). 69(4), 549-555 | en |
dc.identifier.issn | 1365-2265 (Electronic) | - |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=18248646 | - |
dc.identifier.uri | https://hdl.handle.net/10371/68178 | - |
dc.description.abstract | OBJECTIVE: The current consensus algorithm for management of type 2 diabetes is based on the fasting glucose concentration and glycated haemoglobin A(1c) (HbA(1c)) level. We applied a new therapeutic strategy by assessing insulin secretion and insulin resistance, in addition to glucose concentrations in individual patients. DESIGN AND PATIENTS: We enrolled 193 patients with type 2 diabetes. The patients were assigned to one of six groups according to insulin secretion measured by the serum fasting C-peptide concentration and insulin resistance measured by an insulin tolerance test (ITT). The two groups were treated differently: 108 patients were treated using a new staged diabetes management (SDM) strategy and 85 patients continued with conventional therapy. MEASUREMENTS: We compared metabolic variables in the two groups at baseline and 12 months after enrollment. RESULTS: In patients treated with the SDM strategy, fasting glucose concentration decreased from 9.8 +/- 2.1 to 8.2 +/- 1.7 mmol/l (P < 0.001). Postprandial 2-h glucose concentration decreased from 14.19 +/- 3.34 to 12.27 +/- 3.24 mmol/l (P < 0.001). HbA(1c) level decreased from 8.37 +/- 1.42% to 7.72 +/- 1.39% (P < 0.001). About 43% of the new SDM group achieved an HbA(1c) of < 7.0% compared with 25% of patients in the conventional treatment group. CONCLUSIONS: The new SDM strategy, based on individual data on insulin resistance and insulin secretion, may provide valuable clinical benefits in non-obese Korean patients with type 2 diabetes. | en |
dc.description.sponsorship | This study was supported by a grant of the Seoul R & BD Program,
Republic of Korea (10526), by the Brain Korea 21 Project for Medical Science, Yonsei University, and a grant from the Korea Health 21 R&D Project, Ministry of Health and Welfare, Republic of Korea (03-PJ10-PG13-GD01-0002). | en |
dc.language.iso | en | en |
dc.publisher | Wiley-Blackwell | en |
dc.subject | Aged | en |
dc.subject | Algorithms | en |
dc.subject | Blood Glucose/*metabolism | en |
dc.subject | Body Weights and Measures | en |
dc.subject | Clinical Protocols/standards | en |
dc.subject | Diabetes Mellitus, Type 2/blood/metabolism/physiopathology/*therapy | en |
dc.subject | Fasting/blood/metabolism | en |
dc.subject | Female | en |
dc.subject | Hemoglobin A, Glycosylated/analysis | en |
dc.subject | Humans | en |
dc.subject | Individuality | en |
dc.subject | Insulin Resistance/*physiology | en |
dc.subject | Insulin-Secreting Cells/*physiology | en |
dc.subject | Male | en |
dc.subject | Middle Aged | en |
dc.title | Staged diabetes management according to individual patient insulin resistance and beta-cell function ameliorates glycaemic control in type 2 diabetes mellitus | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 최성희 | - |
dc.contributor.AlternativeAuthor | 허규연 | - |
dc.contributor.AlternativeAuthor | 김대정 | - |
dc.contributor.AlternativeAuthor | 안철우 | - |
dc.contributor.AlternativeAuthor | 강은석 | - |
dc.contributor.AlternativeAuthor | 차봉수 | - |
dc.contributor.AlternativeAuthor | 임성길 | - |
dc.contributor.AlternativeAuthor | 허갑법 | - |
dc.contributor.AlternativeAuthor | 이현철 | - |
dc.identifier.doi | 10.1111/j.1365-2265.2008.03199.x | - |
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