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Slow-releasing paclitaxel in polytetrafluoroethylene/polylactide-co-glycolide laminate delays adjustment after strabismus surgery in rabbit model
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Choung, Ho-Kyung | - |
dc.contributor.author | Jin, Su-Eon | - |
dc.contributor.author | Lee, Min Joung | - |
dc.contributor.author | Kim, Chong-Kook | - |
dc.contributor.author | Hwang, Jeong-Min | - |
dc.date.accessioned | 2010-07-04T23:20:32Z | - |
dc.date.available | 2010-07-04T23:20:32Z | - |
dc.date.issued | 2008-08-19 | - |
dc.identifier.citation | Invest Ophthalmol Vis Sci. 2008;49(12):5340-5345 | en |
dc.identifier.issn | 1552-5783 (Electronic) | - |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=18708626 | - |
dc.identifier.uri | http://www.iovs.org/cgi/reprint/49/12/5340.pdf | - |
dc.identifier.uri | https://hdl.handle.net/10371/68197 | - |
dc.description.abstract | PURPOSE: To determine the usefulness of slow-releasing paclitaxelin polytetrafluoroethylene/polylactide-co-glycolide (PTFE/PLGA) laminate for delayed adjustable strabismus surgery. METHODS: A prospective, masked-observer, controlled study was performed in 25 rabbits. Fifty rabbit eyes were divided randomly into three groups. After recession of the superior rectus muscle (SRM), a PTFE/PLGA laminate containing paclitaxel, PTFE alone, or physiologic saline was applied beneath and over the SRM in the PTFE/PLGA-paclitaxel group (group paclitaxel), the PTFE group (group PTFE), and the control group, respectively. Delayed adjustment was performed by a masked observer once on each SRM at 3 or 5 weeks after surgery. Adjustability, adjustment lengths, forces required, and adhesion degrees were evaluated. RESULTS: In the control group, adjustment was impossible in any eye at 3 or 5 weeks after surgery. In group PTFE, adjustment was possible in 5 of 8 eyes at 3 weeks after surgery and in 5 of 10 eyes at 5 weeks after surgery. In group paclitaxel, adjustment was possible in 6 of 9 eyes and in 7 of 7 eyes at 3 and 5 weeks after surgery. On comparing adjustability, a significant difference was observed between group paclitaxel and the control group at 3 and 5 weeks after surgery (P = 0.016 and P = 0.001, respectively). A significant difference was observed between group paclitaxel and the control group (P = 0.003) in terms of adhesion between SRMs and sclera 5 weeks after surgery. CONCLUSIONS: Slow-releasing paclitaxel in PTFE/PLGA was found to reduce adhesion and allowed delayed adjustment in most eyes for up to 5 weeks after surgery. | en |
dc.language.iso | en | en |
dc.publisher | Association for Research in Vision and Ophthalmology (ARVO) | en |
dc.subject | Animals | en |
dc.subject | Delayed-Action Preparations | en |
dc.subject | Lactic Acid | en |
dc.subject | Oculomotor Muscles/*drug effects/surgery | en |
dc.subject | Paclitaxel/*administration & dosage | en |
dc.subject | Polyglycolic Acid | en |
dc.subject | Polytetrafluoroethylene | en |
dc.subject | Postoperative Complications/prevention & control | en |
dc.subject | Prospective Studies | en |
dc.subject | Rabbits | en |
dc.subject | Strabismus/*surgery | en |
dc.subject | Tissue Adhesions/prevention & control | en |
dc.subject | Tubulin Modulators/*administration & dosage | en |
dc.subject | Vision, Binocular | en |
dc.subject | Drug Delivery Systems | - |
dc.subject | Suture Techniques | - |
dc.title | Slow-releasing paclitaxel in polytetrafluoroethylene/polylactide-co-glycolide laminate delays adjustment after strabismus surgery in rabbit model | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 정호경 | - |
dc.contributor.AlternativeAuthor | 진수연 | - |
dc.contributor.AlternativeAuthor | 이민정 | - |
dc.contributor.AlternativeAuthor | 김종국 | - |
dc.contributor.AlternativeAuthor | 황정민 | - |
dc.identifier.doi | 10.1167/iovs.08-1694 | - |
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