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Slow-releasing paclitaxel in polytetrafluoroethylene/polylactide-co-glycolide laminate delays adjustment after strabismus surgery in rabbit model

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dc.contributor.authorChoung, Ho-Kyung-
dc.contributor.authorJin, Su-Eon-
dc.contributor.authorLee, Min Joung-
dc.contributor.authorKim, Chong-Kook-
dc.contributor.authorHwang, Jeong-Min-
dc.date.accessioned2010-07-04T23:20:32Z-
dc.date.available2010-07-04T23:20:32Z-
dc.date.issued2008-08-19-
dc.identifier.citationInvest Ophthalmol Vis Sci. 2008;49(12):5340-5345en
dc.identifier.issn1552-5783 (Electronic)-
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=18708626-
dc.identifier.urihttp://www.iovs.org/cgi/reprint/49/12/5340.pdf-
dc.identifier.urihttps://hdl.handle.net/10371/68197-
dc.description.abstractPURPOSE: To determine the usefulness of slow-releasing paclitaxelin polytetrafluoroethylene/polylactide-co-glycolide (PTFE/PLGA) laminate for delayed adjustable strabismus surgery. METHODS: A prospective, masked-observer, controlled study was performed in 25 rabbits. Fifty rabbit eyes were divided randomly into three groups. After recession of the superior rectus muscle (SRM), a PTFE/PLGA laminate containing paclitaxel, PTFE alone, or physiologic saline was applied beneath and over the SRM in the PTFE/PLGA-paclitaxel group (group paclitaxel), the PTFE group (group PTFE), and the control group, respectively. Delayed adjustment was performed by a masked observer once on each SRM at 3 or 5 weeks after surgery. Adjustability, adjustment lengths, forces required, and adhesion degrees were evaluated. RESULTS: In the control group, adjustment was impossible in any eye at 3 or 5 weeks after surgery. In group PTFE, adjustment was possible in 5 of 8 eyes at 3 weeks after surgery and in 5 of 10 eyes at 5 weeks after surgery. In group paclitaxel, adjustment was possible in 6 of 9 eyes and in 7 of 7 eyes at 3 and 5 weeks after surgery. On comparing adjustability, a significant difference was observed between group paclitaxel and the control group at 3 and 5 weeks after surgery (P = 0.016 and P = 0.001, respectively). A significant difference was observed between group paclitaxel and the control group (P = 0.003) in terms of adhesion between SRMs and sclera 5 weeks after surgery. CONCLUSIONS: Slow-releasing paclitaxel in PTFE/PLGA was found to reduce adhesion and allowed delayed adjustment in most eyes for up to 5 weeks after surgery.en
dc.language.isoenen
dc.publisherAssociation for Research in Vision and Ophthalmology (ARVO)en
dc.subjectAnimalsen
dc.subjectDelayed-Action Preparationsen
dc.subjectLactic Aciden
dc.subjectOculomotor Muscles/*drug effects/surgeryen
dc.subjectPaclitaxel/*administration & dosageen
dc.subjectPolyglycolic Aciden
dc.subjectPolytetrafluoroethyleneen
dc.subjectPostoperative Complications/prevention & controlen
dc.subjectProspective Studiesen
dc.subjectRabbitsen
dc.subjectStrabismus/*surgeryen
dc.subjectTissue Adhesions/prevention & controlen
dc.subjectTubulin Modulators/*administration & dosageen
dc.subjectVision, Binocularen
dc.subjectDrug Delivery Systems-
dc.subjectSuture Techniques-
dc.titleSlow-releasing paclitaxel in polytetrafluoroethylene/polylactide-co-glycolide laminate delays adjustment after strabismus surgery in rabbit modelen
dc.typeArticleen
dc.contributor.AlternativeAuthor정호경-
dc.contributor.AlternativeAuthor진수연-
dc.contributor.AlternativeAuthor이민정-
dc.contributor.AlternativeAuthor김종국-
dc.contributor.AlternativeAuthor황정민-
dc.identifier.doi10.1167/iovs.08-1694-
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