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Pulmonary resection in patients with nonsmall-cell lung cancer treated with gamma-knife radiosurgery for synchronous brain metastases
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Yang, Seung-Yeob | - |
dc.contributor.author | Kim, Dong Gyu | - |
dc.contributor.author | Lee, Se-Hoon | - |
dc.contributor.author | Chung, Hyun-Tai | - |
dc.contributor.author | Paek, Sun Ha | - |
dc.contributor.author | Kim, Joo Hyun | - |
dc.contributor.author | Jung, Hee-Won | - |
dc.contributor.author | Han, Dae Hee | - |
dc.date.accessioned | 2010-07-04T23:25:04Z | - |
dc.date.available | 2010-07-04T23:25:04Z | - |
dc.date.issued | 2008-02-27 | - |
dc.identifier.citation | Cancer. 2008;112(8):1780-1786 | en |
dc.identifier.issn | 0008-543X (Print) | - |
dc.identifier.uri | https://hdl.handle.net/10371/68201 | - |
dc.description.abstract | BACKGROUND: The aim of the current study was to determine whether a pulmonary resection and gamma-knife radiosurgery (GKRS) protocol is superior to GKRS alone in selected patients with stage IV nonsmall-cell lung cancer (NSCLC). METHODS: The authors performed a retrospective case-control study of 232 consecutive patients with newly diagnosed NSCLC from January 1998 to December 2005 and screened them to identify a study cohort in which all patients had thoracic stage I or II, Karnofsky performance status >or= 70, no extracranial metastases, and 1-3 synchronous brain metastases of less than 3 cm, and were treated with GKRS (n=31). The study cohort was divided into 2 groups, those with and without concomitant pulmonary resection. RESULTS: Sixteen patients with pulmonary resection were assigned to the treatment group and 15 without pulmonary resection were assigned to the control group. Median follow-up was 27.3 months (range, 4.4 months to 90.9 months). Mean survivals for the treatment group and the control group were 64.9 and 18.1 months, respectively (P< .001). There was a statistically significant association between pulmonary resection and better survival (OR=78.408). One-year and 5-year local brain tumor control rates were 97.1% and 93.5%, respectively. CONCLUSIONS: The pulmonary resection and GKRS protocol could prolong survival in patients with thoracic stage I or II NSCLC, no extracranial metastases, and a limited number of small synchronous brain metastases. | en |
dc.language.iso | en | en |
dc.publisher | Wiley-Blackwell | en |
dc.subject | Adult | en |
dc.subject | Aged | en |
dc.subject | Antineoplastic Agents/therapeutic use | en |
dc.subject | Antineoplastic Agents, Phytogenic/administration & dosage | en |
dc.subject | Antineoplastic Combined Chemotherapy Protocols/therapeutic use | en |
dc.subject | Brain Neoplasms/*secondary/surgery | en |
dc.subject | Carcinoma, Non-Small-Cell Lung/secondary/*surgery | en |
dc.subject | Case-Control Studies | en |
dc.subject | Chemotherapy, Adjuvant | en |
dc.subject | Cisplatin/administration & dosage | en |
dc.subject | Cohort Studies | en |
dc.subject | Female | en |
dc.subject | Follow-Up Studies | en |
dc.subject | Humans | en |
dc.subject | Lung Neoplasms/*surgery | en |
dc.subject | Male | en |
dc.subject | Middle Aged | en |
dc.subject | Neoplasm Staging | en |
dc.subject | Paclitaxel/administration & dosage | en |
dc.subject | Pneumonectomy/*methods | en |
dc.subject | Radiosurgery/*methods | en |
dc.subject | Retrospective Studies | en |
dc.subject | Survival Rate | en |
dc.title | Pulmonary resection in patients with nonsmall-cell lung cancer treated with gamma-knife radiosurgery for synchronous brain metastases | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 양승엽 | - |
dc.contributor.AlternativeAuthor | 김동규 | - |
dc.contributor.AlternativeAuthor | 이세훈 | - |
dc.contributor.AlternativeAuthor | 정현태 | - |
dc.contributor.AlternativeAuthor | 백선하 | - |
dc.contributor.AlternativeAuthor | 정희원 | - |
dc.contributor.AlternativeAuthor | 한대희 | - |
dc.contributor.AlternativeAuthor | 김주현 | - |
dc.identifier.doi | 10.1002/cncr.23357 | - |
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