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Anti-cyclic citrullinated peptide antibody is associated with radiographic erosion in rheumatoid arthritis independently of shared epitope status

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dc.contributor.authorIm, Churl Hyun-
dc.contributor.authorKang, Eun Ha-
dc.contributor.authorRyu, Hee Jung-
dc.contributor.authorLee, Jung Hwa-
dc.contributor.authorLee, Eun Young-
dc.contributor.authorLee, Yun Jong-
dc.contributor.authorLee, Eun Bong-
dc.contributor.authorSong, Yeong Wook-
dc.date.accessioned2010-07-04T23:29:00Z-
dc.date.available2010-07-04T23:29:00Z-
dc.date.issued2008-08-30-
dc.identifier.citationRheumatol Int. 29(3):251-256en
dc.identifier.issn0172-8172 (Print)-
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=18751982-
dc.identifier.urihttp://www.springerlink.com/content/yp0837j1n67t1004/fulltext.pdf-
dc.identifier.urihttps://hdl.handle.net/10371/68204-
dc.description.abstractShared epitope (SE) and anti-cyclic citrullinated peptide (CCP) antibody are known to be associated with rheumatoid arthritis (RA). The authors investigated their adjusted effects on RA from Korean population. Clinical features were evaluated in 226 RA patients; 164 healthy controls were enrolled. HLA-DRB1 typing for SE was done by polymerase chain reaction. Anti-CCP antibody levels were determined by enzyme linked immunosorbent assay. Logistic regression analysis method was used for adjusted effects. SE and anti-CCP antibody were associated with RA susceptibility. Anti-CCP antibody was associated with RA susceptibility independent of SE [odds ratio, OR 179.9 (95% confidence interval, CI 40.8-792.2), P < 0.001]. Anti-CCP antibody was associated with radiographic erosive changes independent of SE or rheumatoid factor [OR 3.9 (95% CI 1.1-13.3), P = 0.032]. Anti-CCP antibody was strongly associated with RA susceptibility and radiographic erosion of RA patients, independent of SE in Korean.en
dc.description.sponsorshipThis work was supported by the Korea Science
and Engineering Foundation (KOSEF) through the National Research
Lab. Program funded by the Ministry of Science and Technology (No.
ROA-2004-000-10296-0) and partly by a grant from PWzer.
en
dc.language.isoenen
dc.publisherSpringer Verlagen
dc.subjectArthritis, Rheumatoid/blood/*immunology/radiographyen
dc.subjectAutoantibodies/*blooden
dc.subjectEpitopes/*immunologyen
dc.subjectFemaleen
dc.subjectHumansen
dc.subjectKoreaen
dc.subjectMaleen
dc.subjectMiddle Ageden
dc.subjectOdds Ratioen
dc.subjectPeptides, Cyclic/blood/*immunologyen
dc.subjectRetrospective Studiesen
dc.subjectRheumatoid Factor/blooden
dc.titleAnti-cyclic citrullinated peptide antibody is associated with radiographic erosion in rheumatoid arthritis independently of shared epitope statusen
dc.typeArticleen
dc.contributor.AlternativeAuthor임철현-
dc.contributor.AlternativeAuthor강은하-
dc.contributor.AlternativeAuthor류희정-
dc.contributor.AlternativeAuthor이정화-
dc.contributor.AlternativeAuthor이은영-
dc.contributor.AlternativeAuthor이윤종-
dc.contributor.AlternativeAuthor이은봉-
dc.contributor.AlternativeAuthor송영욱-
dc.identifier.doi10.1007/s00296-008-0690-9-
Appears in Collections:
College of Medicine/School of Medicine (의과대학/대학원)Internal Medicine (내과학전공)Journal Papers (저널논문_내과학전공)
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