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Renal expression of galectin-3 in systemic lupus erythematosus patients with nephritis
- Issue Date
- 2008-12-17
- Publisher
- SAGE Publications
- Citation
- Lupus. 2009; 18(1): 22-28
- Keywords
- Adult ; Antibodies, Antinuclear ; Complement C3/metabolism ; Complement C4/metabolism ; DNA/metabolism ; Enzyme-Linked Immunosorbent Assay ; Female ; Galectin 3/*genetics/metabolism ; Humans ; Immunohistochemistry ; Kidney Glomerulus/*metabolism/pathology ; Lupus Erythematosus, Systemic/*genetics ; Lupus Nephritis/*genetics/metabolism ; Male ; Young Adult ; Gene Expression
- Abstract
- The aim of the study is to characterize the expression pattern of galectin-3 (Gal-3) in renal tissues of patients with systemic lupus erythematosus (SLE) nephritis and to determine whether tissue and serum Gal-3 are associated with SLE nephritis. Gal-3 expressions were examined with immunohistochemistry in renal biopsy specimens of 88 patients with SLE nephritis and in five normal specimens. Activity and chronicity indexes and glomerular Gal-3 expressions were analysed in each specimen. Serum Gal-3 levels were measured using enzyme-linked immunosorbent assays in 20 patients with SLE, including 11 with nephritis, and in 50 healthy controls. Glomerular Gal-3 expression was observed in 81.8% (72/88) of patients with SLE nephritis but not in 5 controls. Gal-3 staining was attributed mainly to its cellular expression rather than its deposition, and Gal-3 expression levels were correlated with histologic activity indexes, anti-dsDNA titers, and complement 3 and 4 levels. Serum Gal-3 levels were higher in patients with SLE, particularly in those with nephritis, than in healthy controls, and correlated with anti-dsDNA titers. In conclusion, glomerular Gal-3 expression in renal tissue and serum Gal-3 levels were elevated in patients with SLE nephritis versus healthy controls; moreover, they reflected disease activity. These findings suggest that Gal-3 might contribute to the inflammatory process in SLE.
- ISSN
- 0961-2033 (Print)
- Language
- English
- URI
- http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=19074165
http://lup.sagepub.com/cgi/reprint/18/1/22.pdf
https://hdl.handle.net/10371/68210
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