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Absence of intravitreal bevacizumab-induced neuronal toxicity in the retina

Cited 27 time in Web of Science Cited 28 time in Scopus
Authors
Kim, Jeong Hun; Kim, Cinoo; Kim, Jin Hyoung; Lee, Byung Ju; Yu, Young Suk; Park, Kyu Hyung; Kim, Kyu-Won
Issue Date
2008-07-22
Publisher
Elsevier
Citation
Neurotoxicology. 2008;29(6):1131-1135
Keywords
Age FactorsAngiogenesis Inhibitors/*administration & dosageAnimalsAntibodies, Monoclonal/*administration & dosageCell Line, TumorCell Survival/drug effectsDose-Response Relationship, DrugHumansIn Situ Nick-End LabelingInjections, Intraventricular/methodsMiceMice, Inbred C57BLNeurons/*drug effectsRetina/*cytologyRetinoblastomaTime Factors
Abstract
Bevacizumab is a complete humanized monoclonal antibody directed against all isoforms of vascular endothelial growth factor (VEGF). It was originally used as a first-line treatment for metastatic colorectal cancer. Recently, intravitreal bevacizumab has been effectively applied to vasoproliferative diseases, such as retinal and choroidal neovascularization. However, it is known that intravenous administration of bevacizumab in the treatment of cancer can lead to serious adverse events, such as congestive heart failure, thromboembolism, and neuropathy. In this study, we showed that very high concentrations of intravitreal bevacizumab, even up to 15 times the dose normally used in human clinical applications, (1microl, 25mg/ml), caused no definite histological abnormalities and no significant increase in apoptotic cell death in the mouse retina at 4 weeks after treatment. Moreover, intravitreal bevacizumab induced no neuronal toxicity in the retina. Even in high concentrations, bevacizumab caused no changes in the viability of retinal neurons or the expression of neurofilament, a marker of neuronal differentiation. Therefore, we believe that intravitreal bevacizumab has therapeutic potential for the treatment of retinal and choroidal neovascularization and has the added benefit of exhibiting no acute or chronic toxicity in retinal neurons.
ISSN
0161-813X (Print)
Language
English
URI
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=18639582

http://www.sciencedirect.com/science?_ob=MImg&_imagekey=B6W81-4SVV8D5-1-F&_cdi=6641&_user=168665&_orig=search&_coverDate=11%2F30%2F2008&_sk=999709993&view=c&wchp=dGLbVzb-zSkzS&md5=4259b143b7d9e728e21fc4af061eb2e1&ie=/sdarticle.pdf

https://hdl.handle.net/10371/68215
DOI
https://doi.org/10.1016/j.neuro.2008.06.006
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College of Medicine/School of Medicine (의과대학/대학원)Ophthalmology (안과학전공)Journal Papers (저널논문_안과학전공)
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