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Efficacy of chemotherapy as a first-line treatment in ocular adnexal extranodal marginal zone B-cell lymphoma
DC Field | Value | Language |
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dc.contributor.author | Song, E. -K. | - |
dc.contributor.author | Kim, S. -Y. | - |
dc.contributor.author | Kim, T. M. | - |
dc.contributor.author | Lee, K. -W. | - |
dc.contributor.author | Yun, T. | - |
dc.contributor.author | Na, I. -I. | - |
dc.contributor.author | Shin, H. | - |
dc.contributor.author | Lee, S. H. | - |
dc.contributor.author | Kim, D. W. | - |
dc.contributor.author | Khwarg, S. I. | - |
dc.contributor.author | Heo, D. S. | - |
dc.date.accessioned | 2010-07-05T04:02:00Z | - |
dc.date.available | 2010-07-05T04:02:00Z | - |
dc.date.created | 2020-04-08 | - |
dc.date.issued | 2008-02 | - |
dc.identifier.citation | Annals of Oncology, Vol.19 No.2, pp.242-246 | - |
dc.identifier.issn | 0923-7534 | - |
dc.identifier.other | 95276 | - |
dc.identifier.uri | https://hdl.handle.net/10371/68266 | - |
dc.description.abstract | Background: Radiotherapy is commonly used as a first-line treatment for localized ocular adnexal extranodal marginal zone B-cell lymphoma (EMZBL), despite its ophthalmologic complications. This study was undertaken to analyze the efficacy of first-line chemotherapy in treating EMZBL. Chemotherapy was followed by radiotherapy only in recurrent cases. Patients and methods: Twenty-one patients with histologically confirmed EMZBL were treated with combination of cyclophosphamide, vincristine, and prednisolone (CVP). Radiotherapy was given to CVP failure cases. Results: CVP alone resulted in overall response rate of 100% [complete remission (CR), 76.2%]. After a median follow-up of 58 months, 14 (66.7%) of 21 cases were disease free with CVP alone, while seven cases showed disease progression, including two extra-orbital and five local failures. Radiotherapy was delivered to five local failure cases, who subsequently achieved CR with late ophthalmologic complications. There were tolerable adverse events associated with CVP. Conclusions: Front-line CVP, in conjunction with radiotherapy in recurrent cases, is effective and well tolerated in patients with localized ocular adnexal EMZBL. | - |
dc.language | 영어 | - |
dc.language.iso | en | en |
dc.publisher | Oxford University Press | - |
dc.title | Efficacy of chemotherapy as a first-line treatment in ocular adnexal extranodal marginal zone B-cell lymphoma | - |
dc.type | Article | - |
dc.contributor.AlternativeAuthor | 김동완 | - |
dc.contributor.AlternativeAuthor | 곽상인 | - |
dc.contributor.AlternativeAuthor | 허대석 | - |
dc.identifier.doi | 10.1093/annonc/mdm457 | - |
dc.citation.journaltitle | Annals of Oncology | - |
dc.identifier.wosid | 000253812300007 | - |
dc.identifier.scopusid | 2-s2.0-38849176046 | - |
dc.citation.endpage | 246 | - |
dc.citation.number | 2 | - |
dc.citation.startpage | 242 | - |
dc.citation.volume | 19 | - |
dc.identifier.sci | 000253812300007 | - |
dc.description.isOpenAccess | Y | - |
dc.contributor.affiliatedAuthor | Kim, D. W. | - |
dc.contributor.affiliatedAuthor | Khwarg, S. I. | - |
dc.contributor.affiliatedAuthor | Heo, D. S. | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | NON-HODGKINS-LYMPHOMA | - |
dc.subject.keywordPlus | PRIMARY ORBITAL LYMPHOMA | - |
dc.subject.keywordPlus | MALT LYMPHOMA | - |
dc.subject.keywordPlus | CHLAMYDIA-PSITTACI | - |
dc.subject.keywordPlus | PROGNOSTIC-FACTORS | - |
dc.subject.keywordPlus | TISSUE-TYPE | - |
dc.subject.keywordPlus | RADIOTHERAPY | - |
dc.subject.keywordPlus | THERAPY | - |
dc.subject.keywordPlus | CHLORAMBUCIL | - |
dc.subject.keywordPlus | RITUXIMAB | - |
dc.subject.keywordAuthor | chemotherapy | - |
dc.subject.keywordAuthor | MALT lymphoma | - |
dc.subject.keywordAuthor | ocular adnexal lymphoma | - |
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