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Effects of 60 Hz 14 microT magnetic field on the apoptosis of testicular germ cell in mice

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dc.contributor.authorKim, Yoon-Won-
dc.contributor.authorKim, Hee-Sung-
dc.contributor.authorLee, Jin-Sang-
dc.contributor.authorKim, Young-Jin-
dc.contributor.authorLee, Sang-Kon-
dc.contributor.authorSeo, Jae-Nam-
dc.contributor.authorJung, Kyeong-Cheon-
dc.contributor.authorKim, Nam-
dc.contributor.authorGimm, Youn-Myoung-
dc.date.accessioned2010-07-06T23:23:52Z-
dc.date.available2010-07-06T23:23:52Z-
dc.date.issued2008-10-08-
dc.identifier.citationBioelectromagnetics. 30(1):66-72en
dc.identifier.issn1521-186X (Electronic)-
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=18839413-
dc.identifier.urihttps://hdl.handle.net/10371/68356-
dc.description.abstractWe recently reported that continuous exposure, for 8 weeks, of extremely low frequency (ELF) magnetic field (MF) of 0.1 or 0.5 mT might induce testicular germ cell apoptosis in BALB/c mice. In that report, the ELF MF exposure did not significantly affect the body weight or testicular weight, but significantly increased the incidence of testicular germ cell death. In the present study, we aimed to further characterize the effect of a 16-week continuous exposure to ELF MF of 14 or 200 microT on testicular germ cell apoptosis in mice. There were no significant effects of MF on body weight and testosterone levels in mice. In TUNEL staining (In situ terminal deoxynucleotidyl transferase-mediated deoxy-UTP nick end labeling), germ cells showed a significantly higher apoptotic rate in exposed mice than in sham controls (P < 0.001). TUNEL-positive cells were mainly spermatogonia. In an electron microscopic study, degenerating spermatogonia showed condensation of nuclear chromatin similar to apoptosis. These results indicate that apoptosis may be induced in spermatogenic cells in mice by continuous exposure to 60 Hz MF of 14 microT.en
dc.language.isoenen
dc.publisherWiley-Blackwellen
dc.subjectAnimalsen
dc.subjectApoptosis/*radiation effectsen
dc.subjectCells, Cultureden
dc.subjectDose-Response Relationship, Radiationen
dc.subjectElectricityen
dc.subjectElectromagnetic Fieldsen
dc.subjectMaleen
dc.subjectMiceen
dc.subjectMice, Inbred BALB Cen
dc.subjectRadiation Dosageen
dc.subjectSpermatozoa/cytology/*physiology/*radiation effectsen
dc.subjectTestis/cytology/*physiology/*radiation effectsen
dc.titleEffects of 60 Hz 14 microT magnetic field on the apoptosis of testicular germ cell in miceen
dc.typeArticleen
dc.contributor.AlternativeAuthor김윤원-
dc.contributor.AlternativeAuthor김희성-
dc.contributor.AlternativeAuthor이진상-
dc.contributor.AlternativeAuthor김영진-
dc.contributor.AlternativeAuthor이상곤-
dc.contributor.AlternativeAuthor서재남-
dc.contributor.AlternativeAuthor정경천-
dc.contributor.AlternativeAuthor김남-
dc.contributor.AlternativeAuthor김윤명-
dc.identifier.doi10.1002/bem.20448-
Appears in Collections:
College of Medicine/School of Medicine (의과대학/대학원)Pathology (병리학전공)Journal Papers (저널논문_병리학전공)
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