Publications
Detailed Information
Phosphorylation of ERK1/2 and prognosis of clear cell renal cell carcinoma
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, Hyun Ju | - |
dc.contributor.author | Kim, Dong-Il | - |
dc.contributor.author | Kang, Gyeong Hoon | - |
dc.contributor.author | Kwak, Cheol | - |
dc.contributor.author | Ku, Ja Hyeon | - |
dc.contributor.author | Moon, Kyung Chul | - |
dc.date.accessioned | 2010-07-07 | - |
dc.date.available | 2010-07-07 | - |
dc.date.issued | 2008-10-14 | - |
dc.identifier.citation | Urology. 2009;73(2):394-399 | en |
dc.identifier.issn | 1527-9995 (Electronic) | - |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=18849062 | - |
dc.identifier.uri | http://www.sciencedirect.com/science?_ob=MImg&_imagekey=B6VJW-4TN5MCV-1-5&_cdi=6105&_user=168665&_orig=search&_coverDate=02%2F28%2F2009&_sk=999269997&view=c&wchp=dGLzVtb-zSkWz&md5=445ad4456c1cf1c73ffb9bc8b176b197&ie=/sdarticle.pdf | - |
dc.identifier.uri | https://hdl.handle.net/10371/68373 | - |
dc.description.abstract | OBJECTIVES: To evaluate the phosphorylation of extracellular signal-regulated kinases 1/2 (ERK1/2) in clear cell renal cell carcinoma (CCRCC) and to investigate its prognostic significance. ERK1/2 activation had been reported in RCC, but little is known about its prognostic significance. METHODS: We immunohistochemically analyzed phosphorylated ERK1/2 (pERK) expression using tissue microarrays in 328 CCRCC specimens. The percentage of tumor cells showing positive staining was evaluated and classified into 4 categories: 0, 0%; 1+, 1%-10%; 2+, 11%-50%; and 3+, > 50%. For statistical analysis, the cases were subdivided into pERK-low (0 and 1+) and pERK-high (2+ and 3+) expression. RESULTS: Our study showed significantly greater expression of pERK in CCRCC than in non-neoplastic renal parenchyma. pERK-high expression was significantly associated with a low pT category (P = .046). The survival analysis showed a significant association between pERK-high expression and better progression-free survival (P = .014). Furthermore, the prognostic significance of pERK expression was quite different between small CCRCC (size < or = 7 cm) and large CCRCC (size > 7 cm) lesions. In small CCRCC, pERK-high expression correlated significantly with better cancer-specific survival (P = .018) and better progression-free survival (P < .001). However, no correlation was found between pERK expression and survival in large CCRCC. CONCLUSIONS: High expression of pERK in CCRCC was associated with a low pT category and showed a longer progression-free survival, especially in small CCRCC. Although the biologic mechanism of the ERK pathway in CCRCC remains unknown, the results of this study suggest that pERK expression is a positive prognosticator for survival in those with small CCRCC. | en |
dc.language.iso | en | - |
dc.publisher | Elsevier | en |
dc.subject | Carcinoma, Renal Cell/*metabolism/mortality | en |
dc.subject | Female | en |
dc.subject | Humans | en |
dc.subject | Kidney Neoplasms/*metabolism/mortality | en |
dc.subject | Male | en |
dc.subject | Middle Aged | en |
dc.subject | Mitogen-Activated Protein Kinase 3/biosynthesis/*metabolism | en |
dc.subject | Phosphorylation | en |
dc.subject | Prognosis | en |
dc.subject | Survival Analysis | en |
dc.title | Phosphorylation of ERK1/2 and prognosis of clear cell renal cell carcinoma | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 이현주 | - |
dc.contributor.AlternativeAuthor | 김동일 | - |
dc.contributor.AlternativeAuthor | 곽철 | - |
dc.contributor.AlternativeAuthor | 구자현 | - |
dc.contributor.AlternativeAuthor | 문경철 | - |
dc.contributor.AlternativeAuthor | 강경훈 | - |
dc.identifier.doi | 10.1016/j.urology.2008.08.472 | - |
- Appears in Collections:
- Files in This Item:
- There are no files associated with this item.
Item View & Download Count
Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.