S-Space College of Medicine/School of Medicine (의과대학/대학원) Pathology (병리학전공) Journal Papers (저널논문_병리학전공)
MHC class II-dependent T-T interactions create a diverse, functional and immunoregulatory reaction circle
|dc.contributor.author||Lee, You Jeong||-|
|dc.contributor.author||Jung, Kyeong Cheon||-|
|dc.contributor.author||Park, Seong Hoe||-|
|dc.identifier.citation||Immunol Cell Biol. 2009; 87(1): 65-71||en|
|dc.description.abstract||Unlike conventional T cells, innate-like T cells such as natural killer (NK) T cells are selected by homotypic T-cell interactions. Recently, a few reports have shown that T-T CD4(+) T cells can be generated in a similar manner to that for NKT cells. These two types of cells share common functional properties such as rapid response to antigenic encounters and the potential for a panoply of cytokine secretion. However, T-T CD4(+) T cells differ from NKT cells in that they are restricted by highly polymorphic major histocompatibility complex (MHC) II molecules and have a diverse T-cell receptor repertoire. Additional example of T-T interactions was recently reported in which peripheral T cells re-circulate to the thymus and participate in the thymocyte selection process. In this review, we dissect the cellular mechanisms underlying the production of T-T CD4(+) and NKT cells, with particular emphasis on the differences between these two T-cell prototypes. Finally, we propose that T-T CD4(+) T cells serve two major functions: one as an acute-phase reactant against viral infection and the other is the generation of anti-ergotypic CD4(+) T cells for regulatory purposes. All of these features make it possible to create a diverse set of functional cells through MHC class II-restricted T-T interactions.||en|
|dc.description.sponsorship||This work was supported by a Korean Science and Engineering Foundation
Grant (R01-2007-000-20165-0) from the Ministry of Knowledge Economy
(MKE) of Korea.
|dc.subject||Histocompatibility Antigens Class II/*immunology||en|
|dc.subject||Natural Killer T-Cells/*immunology||en|
|dc.title||MHC class II-dependent T-T interactions create a diverse, functional and immunoregulatory reaction circle||en|
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