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Impact of neurological and medical complications on 3-month outcomes in acute ischaemic stroke

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dc.contributor.authorHong, K-S-
dc.contributor.authorKang, D-W-
dc.contributor.authorKoo, J-S-
dc.contributor.authorYu, K-H-
dc.contributor.authorHan, M-K-
dc.contributor.authorCho, Y-J-
dc.contributor.authorPark, J-M-
dc.contributor.authorBae, H-J-
dc.contributor.authorLee, B-C-
dc.date.accessioned2010-07-07T01:24:03Z-
dc.date.available2010-07-07T01:24:03Z-
dc.date.issued2008-12-04-
dc.identifier.citationEur J Neurol. 2008; 15(12): 1324-1331en
dc.identifier.issn1468-1331 (Electronic)-
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=19049549-
dc.identifier.urihttp://hdl.handle.net/10371/68390-
dc.description.abstractOBJECTIVE: To evaluate the impact of neurological and medical complications on 3-month outcomes in acute ischaemic stroke patients. METHODS: We prospectively investigated complications for all the consecutive acute ischaemic stroke patients admitted within 7 days from onset in four university hospitals during a 1-year period. Baseline data and 3-month outcomes were collected. Poor outcome was defined as a modified Rankin Scale score 3-6. RESULTS: A total of 1 254 patients were recruited: 264 (21.1%) and 303 (24.2%) patients experienced one or more neurological and medical complications, respectively. The most common complications were ischaemic stroke progression (17.1%) and pneumonia (12.0%). Of 1 233 patients with available 3-month outcomes, 34.9% had a poor outcome. Multivariate analysis revealed that neurological (odds ratio, 95% confidence interval; 5.47, 3.63-8.24) and medical (3.47, 2.30-5.23) complications were independent predictors of the poor outcome. For the individual complications, ischaemic stroke progression (7.48, 4.73-11.84), symptomatic hemorrhagic transformation (3.57, 1.33-9.54), pneumonia (4.44, 2.20-8.99), extracranial bleeding (4.45, 1.88-10.53), and urinary tract infection (2.72, 1.32-5.60) were independently associated with the poor outcome. CONCLUSION: Outcome after ischaemic stroke is adversely influenced by complications, especially ischaemic stroke progression, symptomatic hemorrhagic transformation, pneumonia, extracranial bleeding, and urinary tract infection. Interventions to prevent those complications might improve ischaemic stroke outcome.en
dc.description.sponsorshipThis work was supported by the grant of Korean Stroke
Society (KSS-04-002) and the grant of the Korea
Health 21 R&D Project, Ministry of Health & Welfare,
Republic of Korea (A06-0171-B51004-06N1-00010A).
en
dc.language.isoen-
dc.publisherWiley-Blackwellen
dc.subjectAcute Diseaseen
dc.subjectAgeden
dc.subjectBrain Ischemia/*complications/mortalityen
dc.subjectCerebral Hemorrhage/etiology/mortalityen
dc.subjectDiabetes Complications/mortalityen
dc.subjectFemaleen
dc.subjectHemorrhage/etiology/mortalityen
dc.subjectHumansen
dc.subjectHyperlipidemias/complications/mortalityen
dc.subjectHypertension/complications/mortalityen
dc.subjectIncidenceen
dc.subjectKorea/epidemiologyen
dc.subjectMaleen
dc.subjectMiddle Ageden
dc.subjectMortality/trendsen
dc.subjectPneumonia/etiology/mortalityen
dc.subjectPrognosisen
dc.subjectProspective Studiesen
dc.subjectRisk Factorsen
dc.subjectSmoking/adverse effectsen
dc.subjectStroke/*complications/mortalityen
dc.subjectTime Factorsen
dc.subjectUrinary Tract Infections/etiology/mortalityen
dc.titleImpact of neurological and medical complications on 3-month outcomes in acute ischaemic strokeen
dc.typeArticleen
dc.identifier.doi10.1111/j.1468-1331.2008.02310.x-
Appears in Collections:
College of Medicine/School of Medicine (의과대학/대학원)Dept. of Neurology (신경과학교실)Journal Papers (저널논문_신경과학교실)
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