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High correlations between primary tumours and loco-regional metastatic lymph nodes in non-small-cell lung cancer with respect to glucose transporter type 1-mediated 2-deoxy-2-F18-fluoro-D-glucose uptake
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Nguyen, Xuan Canh | - |
dc.contributor.author | So, Young | - |
dc.contributor.author | Chung, Jin-Haeng | - |
dc.contributor.author | Lee, Won Woo | - |
dc.contributor.author | Park, So Yeon | - |
dc.contributor.author | Kim, Sang Eun | - |
dc.date.accessioned | 2010-07-07T01:32:26Z | - |
dc.date.available | 2010-07-07T01:32:26Z | - |
dc.date.issued | 2008-03-04 | - |
dc.identifier.citation | Eur J Cancer. 2008;44(5):692-698 | en |
dc.identifier.issn | 0959-8049 (Print) | - |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=18314327 | - |
dc.identifier.uri | http://www.sciencedirect.com/science?_ob=MImg&_imagekey=B6T68-4S0R6MP-4-F&_cdi=5024&_user=168665&_orig=search&_coverDate=03%2F31%2F2008&_sk=999559994&view=c&wchp=dGLzVtb-zSkzS&md5=6bab53a4bba37f6de8a20e9345f3c715&ie=/sdarticle.pdf | - |
dc.identifier.uri | https://hdl.handle.net/10371/68398 | - |
dc.description.abstract | The purpose of the study was to investigate whether glucose transporter type 1 (Glut-1) mediated 2-deoxy-2-F18-fluoro-D-glucose (FDG) uptake of primary tumour is related to the likelihood of malignancy involvement in loco-regional lymph nodes (LNs) in 126 non-small-cell lung cancer (NSCLC) patients (M:F=103:23, age=65+/-9.7 years). Maximum standardised uptake values (maxSUV) and Glut-1 expression levels (determined by PET and immunostaining, respectively) of primary tumours and PET positive loco-regional LNs were compared. Significant correlations were found between malignant LNs and primary tumours with respect to maxSUV (r=0.6451, p<0.0001), %Glut-1 expression (r=0.8341, p<0.0001) and Glut-1 staining intensity (rho=0.827, p<0.0001). The area-under-curve value for LN differentiation using lymph node maxSUV was significantly higher in patients with a primary tumour maxSUV of >6 (AUC=0.775, p=0.0001). High correlations between the primary tumours and metastatic LNs in NSCLC with respect to the Glut-1 mediated FDG uptake may be useful for mediastinal LN discrimination by FDG-PET. | en |
dc.description.sponsorship | This work was supported by the Korea Research
Foundation Grant funded by the Korean Government (MOEHRD) (KRF-2007-331-E00168), and by the Korea Science and Engineering Foundation (KOSEF) Grant funded by the Korean government (MOST) (No. 2007-00832). Dr. So was supported by the Second-phase of BK (Brain Korea) 21 Project in 2007. | en |
dc.language.iso | en | en |
dc.publisher | Elsevier | en |
dc.subject | Aged | en |
dc.subject | Carcinoma, Non-Small-Cell Lung/*metabolism/radionuclide imaging/secondary | en |
dc.subject | Female | en |
dc.subject | Fluorodeoxyglucose F18/*pharmacokinetics | en |
dc.subject | Glucose Transporter Type 1/*metabolism | en |
dc.subject | Humans | en |
dc.subject | Lung Neoplasms/*metabolism/radionuclide imaging | en |
dc.subject | Lymphatic Metastasis/radionuclide imaging | en |
dc.subject | Male | en |
dc.subject | Positron-Emission Tomography/methods | en |
dc.subject | Radiopharmaceuticals/*pharmacokinetics | en |
dc.subject | Sensitivity and Specificity | en |
dc.title | High correlations between primary tumours and loco-regional metastatic lymph nodes in non-small-cell lung cancer with respect to glucose transporter type 1-mediated 2-deoxy-2-F18-fluoro-D-glucose uptake | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 소영 | - |
dc.contributor.AlternativeAuthor | 정진행 | - |
dc.contributor.AlternativeAuthor | 이원우 | - |
dc.contributor.AlternativeAuthor | 박소연 | - |
dc.contributor.AlternativeAuthor | 김상은 | - |
dc.identifier.doi | 10.1016/j.ejca.2008.02.009 | - |
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