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Frontal lobe epilepsy: clinical characteristics, surgical outcomes and diagnostic modalities
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, Jung Ju | - |
dc.contributor.author | Lee, Sang Kun | - |
dc.contributor.author | Lee, Seo-Young | - |
dc.contributor.author | Park, Kyung-Il | - |
dc.contributor.author | Kim, Dong Wook | - |
dc.contributor.author | Lee, Dong Soo | - |
dc.contributor.author | Chung, Chun Kee | - |
dc.contributor.author | Nam, Hyeon Woo | - |
dc.date.accessioned | 2010-07-07T03:50:45Z | - |
dc.date.available | 2010-07-07T03:50:45Z | - |
dc.date.issued | 2008-03-11 | - |
dc.identifier.citation | Seizure. 2008;17(6):514-523 | en |
dc.identifier.issn | 1059-1311 (Print) | - |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=18329907 | - |
dc.identifier.uri | http://www.sciencedirect.com/science?_ob=MImg&_imagekey=B6WWW-4S1BX7Y-2-3&_cdi=7141&_user=168665&_orig=search&_coverDate=09%2F30%2F2008&_sk=999829993&view=c&wchp=dGLzVlz-zSkWz&md5=753b017fc8980b5b975d6b075cf3d495&ie=/sdarticle.pdf | - |
dc.identifier.uri | https://hdl.handle.net/10371/68433 | - |
dc.description.abstract | OBJECTIVE: To identify surgical prognostic factors and to characterize clinical features according to the location of the intracranial ictal onset zone of frontal lobe epilepsy (FLE) in order to assess the role of various diagnostic modalities, including concordances with presurgical evaluations. METHODS: We studied 71 FLE patients who underwent epilepsy surgery and whose outcomes were followed for more than 2 years. Diagnoses were established by standard presurgical evaluation. RESULTS: Clinical manifestations could be categorized into six types: initial focal motor (9 patients), initial versive seizure (15), frontal lobe complex partial seizure (14), complex partial seizure mimicking temporal lobe epilepsy (18), initial tonic elevation of arms (11), and sudden secondary generalized tonic-clonic seizure (4). Thirty-seven patients became seizure-free after surgery. Five patients were deleted in the analysis because of incomplete resection of ictal onset zones. The positive predictive value of interictal EEG, ictal EEG, MRI, PET, and ictal SPECT, respectively were 62.5%, 56.4%, 73.9%, 63.2%, and 63.6%, and the negative predictive value were 46.0%, 44.4%, 53.5%, 44.7%, and 51.7%. No significant relationship was found between the diagnostic accuracy of these modalities and surgical outcome, with the exception of MRI (p=0.029). Significant concordance of two or more modalities was observed in patients who became seizure-free (p=0.011). We could not find any clinical characteristic related to surgical outcome besides seizure frequency. No definite relationship was found between the location of intracranial ictal onset zone and clinical semiology. CONCLUSION: Although various diagnostic methods can be useful in the diagnosis of FLE, only MRI can predict surgical outcome. Concordance between presurgical evaluations indicates a better surgical outcome. | en |
dc.language.iso | en | en |
dc.publisher | Elsevier | en |
dc.subject | Adolescent | en |
dc.subject | Adult | en |
dc.subject | Child | en |
dc.subject | Diagnostic Imaging/*methods | en |
dc.subject | Electroencephalography/methods | en |
dc.subject | Epilepsy, Frontal Lobe/*diagnosis/*surgery | en |
dc.subject | Female | en |
dc.subject | Fluorodeoxyglucose F18/diagnostic use | en |
dc.subject | Follow-Up Studies | en |
dc.subject | Humans | en |
dc.subject | Magnetic Resonance Imaging | en |
dc.subject | Male | en |
dc.subject | Middle Aged | en |
dc.subject | Neurosurgical Procedures/*methods | en |
dc.subject | Positron-Emission Tomography | en |
dc.subject | Retrospective Studies | en |
dc.subject | Technetium Tc 99m Exametazime | en |
dc.subject | Tomography, Emission-Computed, Single-Photon | en |
dc.subject | Tomography, X-Ray Computed | en |
dc.subject | Treatment Outcome | en |
dc.title | Frontal lobe epilepsy: clinical characteristics, surgical outcomes and diagnostic modalities | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 이정주 | - |
dc.contributor.AlternativeAuthor | 이상건 | - |
dc.contributor.AlternativeAuthor | 이서영 | - |
dc.contributor.AlternativeAuthor | 박경일 | - |
dc.contributor.AlternativeAuthor | 김동욱 | - |
dc.contributor.AlternativeAuthor | 이동수 | - |
dc.contributor.AlternativeAuthor | 정천기 | - |
dc.contributor.AlternativeAuthor | 남현우 | - |
dc.identifier.doi | 10.1016/j.seizure.2008.01.007 | - |
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