Publications
Detailed Information
Endothelial dysfunction and C-reactive protein in relation with the severity of obstructive sleep apnea syndrome
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Chung, Seockhoon | - |
dc.contributor.author | Yoon, In-Young | - |
dc.contributor.author | Shin, Yoon-Kyung | - |
dc.contributor.author | Lee, Chul Hee | - |
dc.contributor.author | Kim, Jeong-Whun | - |
dc.contributor.author | Lee, Taeseung | - |
dc.contributor.author | Choi, Dong-Ju | - |
dc.contributor.author | Ahn, Hee Jeong | - |
dc.date.accessioned | 2010-07-07T10:51:29Z | - |
dc.date.available | 2010-07-07T10:51:29Z | - |
dc.date.issued | 2007-08-19 | - |
dc.identifier.citation | Sleep. 2007;30(8):997-1001 | en |
dc.identifier.issn | 0161-8105 (Print) | - |
dc.identifier.uri | https://hdl.handle.net/10371/68458 | - |
dc.description.abstract | STUDY OBJECTIVES: To investigate flow-mediated dilatation (FMD) and C-reactive protein (CRP) levels in patients with obstructive sleep apnea syndrome (OSAS) in relation with the severity of respiratory disturbances and hypoxemia. DESIGN: After subjects had completed nocturnal polysomnography, FMD was measured in the brachial artery, and blood samples were obtained to determine serum CRP levels. SETTING: Sleep laboratory in Seoul National University Bundang Hospital. PATIENTS: Ninety men: 22 normal controls, 28 subjects with mild to moderate OSAS, and 40 with severe OSAS. MEASUREMENTS AND RESULTS: FMD was found to be correlated with oxygen desaturation index (ODI), percentage of time below 90% O2 saturation, average O2 saturation, lowest O2 saturation, systolic blood pressure, apnea hypopnea index (AHI), and body mass index. In addition, CRP was correlated with body mass index, waist-to-hip ratio, neck circumference, diastolic pressure, average O2 saturation and percentage of time below 90% O2 saturation but not with AHI. Stepwise multiple regression showed that the ODI was a significant determinant of FMD (adjusted R2 = 10%, beta = -0.33, P < 0.01). In addition, body mass index (beta = 0.25, P < 0.05) and waist-to-hip ratio (beta = 0.21, P < 0.05) were found to be significantly correlated with CRP (adjusted R2 = 12%, P < 0.05), independently of other factors. There was no correlation between FMD and CRP. CONCLUSION: As a marker of nocturnal hypoxemia, ODI rather than AHI might better explain the relationship between OSAS and FMD. Because body mass index and waist-to-hip ratio were identified as risk factors of high serum CRP in OSAS, obesity should be considered when predicting cardiovascular complications in OSAS. | en |
dc.language.iso | en | en |
dc.publisher | American Academy of Sleep Medicine | en |
dc.subject | Adult | en |
dc.subject | Anoxia/blood/diagnosis | en |
dc.subject | Body Mass Index | en |
dc.subject | C-Reactive Protein/*metabolism | en |
dc.subject | Endothelium, Vascular/*physiopathology | en |
dc.subject | Female | en |
dc.subject | Humans | en |
dc.subject | Male | en |
dc.subject | Middle Aged | en |
dc.subject | Obesity/blood | en |
dc.subject | Oxygen/blood | en |
dc.subject | Risk Factors | en |
dc.subject | Sleep Apnea, Obstructive/*blood/diagnosis | en |
dc.subject | Vasodilation/physiology | en |
dc.subject | Waist-Hip Ratio | en |
dc.subject | Polysomnography | - |
dc.title | Endothelial dysfunction and C-reactive protein in relation with the severity of obstructive sleep apnea syndrome | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 정석훈 | - |
dc.contributor.AlternativeAuthor | 윤인영 | - |
dc.contributor.AlternativeAuthor | 신윤경 | - |
dc.contributor.AlternativeAuthor | 이철희 | - |
dc.contributor.AlternativeAuthor | 김정훈 | - |
dc.contributor.AlternativeAuthor | 이태성 | - |
dc.contributor.AlternativeAuthor | 최동주 | - |
dc.contributor.AlternativeAuthor | 안희정 | - |
- Appears in Collections:
- Files in This Item:
- There are no files associated with this item.
Item View & Download Count
Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.