S-Space College of Medicine/School of Medicine (의과대학/대학원) Psychiatry (정신과학전공) Journal Papers (저널논문_정신과학전공)
Neural correlates of the Clock Drawing Test performance in Alzheimer's disease: a FDG-PET study
- Lee, Dong Young; Seo, Eun Hyun; Choo, Il Han; Kim, Shin Gyeom; Lee, Jae Sung; Lee, Dong Su; Jhoo, Jin Hyeong; Kim, Ki Woong; Youn, Jong Choul; Woo, Jong Inn
- Issue Date
- Dement Geriatr Cogn Disord. 26(4):306-313
- Aged; Alzheimer Disease/*psychology/*radionuclide imaging; Brain Chemistry/physiology; Brain Mapping; Data Interpretation, Statistical; Female; Fluorodeoxyglucose F18/diagnostic use; Functional Laterality/physiology; Glucose/metabolism; Humans; Image Processing, Computer-Assisted; Male; *Neuropsychological Tests; Parietal Lobe/metabolism/radionuclide imaging; Positron-Emission Tomography; Radiopharmaceuticals/diagnostic use
- BACKGROUND/AIM: This study aimed to identify the functional neuroanatomical correlates of impaired clock drawing test (CDT) performance in patients with Alzheimer's disease (AD). METHOD: The CDT was administered to 71 patients with AD, and regional cerebral glucose metabolism (rCMglc) was measured by positron emission tomography (PET). Correlations between CDT scores and rCMglc were examined on a voxel-by-voxel basis. RESULTS: Significant positive correlations were found between CDT performance and rCMglc in the right inferior parietal lobule and right posterior cingulate cortex. CONCLUSION: These results provide the first PET evidence that poor CDT performance in patients with AD is closely related to the functional decline in the right hemisphere, especially the right parietal cortex.
- 1421-9824 (Electronic)
- Files in This Item: There are no files associated with this item.