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Neural correlates of the Clock Drawing Test performance in Alzheimer's disease: a FDG-PET study

Cited 26 time in Web of Science Cited 27 time in Scopus
Authors
Lee, Dong Young; Seo, Eun Hyun; Choo, Il Han; Kim, Shin Gyeom; Lee, Jae Sung; Lee, Dong Su; Jhoo, Jin Hyeong; Kim, Ki Woong; Youn, Jong Choul; Woo, Jong Inn
Issue Date
2008-10-09
Publisher
Karger
Citation
Dement Geriatr Cogn Disord. 26(4):306-313
Keywords
AgedAlzheimer Disease/*psychology/*radionuclide imagingBrain Chemistry/physiologyBrain MappingData Interpretation, StatisticalFemaleFluorodeoxyglucose F18/diagnostic useFunctional Laterality/physiologyGlucose/metabolismHumansImage Processing, Computer-AssistedMale*Neuropsychological TestsParietal Lobe/metabolism/radionuclide imagingPositron-Emission TomographyRadiopharmaceuticals/diagnostic use
Abstract
BACKGROUND/AIM: This study aimed to identify the functional neuroanatomical correlates of impaired clock drawing test (CDT) performance in patients with Alzheimer's disease (AD). METHOD: The CDT was administered to 71 patients with AD, and regional cerebral glucose metabolism (rCMglc) was measured by positron emission tomography (PET). Correlations between CDT scores and rCMglc were examined on a voxel-by-voxel basis. RESULTS: Significant positive correlations were found between CDT performance and rCMglc in the right inferior parietal lobule and right posterior cingulate cortex. CONCLUSION: These results provide the first PET evidence that poor CDT performance in patients with AD is closely related to the functional decline in the right hemisphere, especially the right parietal cortex.
ISSN
1421-9824 (Electronic)
Language
English
URI
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=18841015

http://content.karger.com/ProdukteDB/produkte.asp?Aktion=ShowPDF&ArtikelNr=000161055&Ausgabe=240296&ProduktNr=224226&filename=000161055.pdf

https://hdl.handle.net/10371/68468
DOI
https://doi.org/10.1159/000161055
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College of Medicine/School of Medicine (의과대학/대학원)Psychiatry (정신과학전공)Journal Papers (저널논문_정신과학전공)
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