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Desipramine inhibits Na+/H+ exchange in human submandibular cells

Cited 7 time in Web of Science Cited 7 time in Scopus
Authors
Choi, S.-Y.; Li, J.; Jo, S.-H.; Lee, S.J.; Oh, S.B.; Kim, J.-S.; Lee, J.-H.; Park, K.
Issue Date
2006
Publisher
American and International Associations for Dental
Citation
J Dent Res 85(9):839-843
Keywords
desipraminexerostomiaintracellular pHNa+/H+ exchangesecretion
Abstract
A common and significant side-effect of the
antidepressant desipramine is xerostomia (dry
mouth). We investigated the effect of desipramine
on Na+/H+ exchanger, which is an important
modulator of salivary secretion. In dissociated
human submandibular acinar cells, desipramine
inhibited intracellular pH recovery in a
concentration-dependent manner. Likewise, 5-(Nethyl-
N-isopropyl)amiloride (EIPA), a Na+/H+
exchanger inhibitor, had the same effect as
desipramine, whereas the effect of 4,4-
diisothiocyanostilbene-2,2-disulphonic acid
(DIDS), a Na+/HCO3
- co-transporter inhibitor, was
not dramatic. Although desipramine is known to
inhibit catecholamine re-uptake, desipramine also
inhibited pH recovery in the human
submandibular gland cell line, HSG cells, which
lack nerve inputs. Our results suggest that
desipramine directly inhibits Na+/H+ exchange in
human submandibular glands without the
involvement of catecholamine re-uptake, revealing
the cellular mechanism of desipramine-evoked
xerostomia.
ISSN
0022-0345
Language
English
URI
https://hdl.handle.net/10371/68573
DOI
https://doi.org/10.1177/154405910608500912
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College of Dentistry/School of Dentistry (치과대학/치의학대학원)Dept. of Dentistry (치의학과)Journal Papers (저널논문_치의학과)
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