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College of Dentistry/School of Dentistry (치과대학/치의학대학원)
Dept. of Dentistry (치의학과)
Journal Papers (저널논문_치의학과)
Desipramine inhibits Na+/H+ exchange in human submandibular cells
- Issue Date
- 2006
- Citation
- J Dent Res 85(9):839-843
- Keywords
- desipramine ; xerostomia ; intracellular pH ; Na+/H+ exchange ; secretion
- Abstract
- A common and significant side-effect of the
antidepressant desipramine is xerostomia (dry
mouth). We investigated the effect of desipramine
on Na+/H+ exchanger, which is an important
modulator of salivary secretion. In dissociated
human submandibular acinar cells, desipramine
inhibited intracellular pH recovery in a
concentration-dependent manner. Likewise, 5-(Nethyl-
N-isopropyl)amiloride (EIPA), a Na+/H+
exchanger inhibitor, had the same effect as
desipramine, whereas the effect of 4,4-
diisothiocyanostilbene-2,2-disulphonic acid
(DIDS), a Na+/HCO3
- co-transporter inhibitor, was
not dramatic. Although desipramine is known to
inhibit catecholamine re-uptake, desipramine also
inhibited pH recovery in the human
submandibular gland cell line, HSG cells, which
lack nerve inputs. Our results suggest that
desipramine directly inhibits Na+/H+ exchange in
human submandibular glands without the
involvement of catecholamine re-uptake, revealing
the cellular mechanism of desipramine-evoked
xerostomia.
- ISSN
- 0022-0345
- Language
- English
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