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Desipramine inhibits Na+/H+ exchange in human submandibular cells
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Choi, S.-Y. | - |
dc.contributor.author | Li, J. | - |
dc.contributor.author | Jo, S.-H. | - |
dc.contributor.author | Lee, S.J. | - |
dc.contributor.author | Oh, S.B. | - |
dc.contributor.author | Kim, J.-S. | - |
dc.contributor.author | Lee, J.-H. | - |
dc.contributor.author | Park, K. | - |
dc.date.accessioned | 2010-07-12T01:07:00Z | - |
dc.date.available | 2010-07-12T01:07:00Z | - |
dc.date.issued | 2006 | - |
dc.identifier.citation | J Dent Res 85(9):839-843 | en |
dc.identifier.issn | 0022-0345 | - |
dc.identifier.uri | https://hdl.handle.net/10371/68573 | - |
dc.description.abstract | A common and significant side-effect of the
antidepressant desipramine is xerostomia (dry mouth). We investigated the effect of desipramine on Na+/H+ exchanger, which is an important modulator of salivary secretion. In dissociated human submandibular acinar cells, desipramine inhibited intracellular pH recovery in a concentration-dependent manner. Likewise, 5-(Nethyl- N-isopropyl)amiloride (EIPA), a Na+/H+ exchanger inhibitor, had the same effect as desipramine, whereas the effect of 4,4- diisothiocyanostilbene-2,2-disulphonic acid (DIDS), a Na+/HCO3 - co-transporter inhibitor, was not dramatic. Although desipramine is known to inhibit catecholamine re-uptake, desipramine also inhibited pH recovery in the human submandibular gland cell line, HSG cells, which lack nerve inputs. Our results suggest that desipramine directly inhibits Na+/H+ exchange in human submandibular glands without the involvement of catecholamine re-uptake, revealing the cellular mechanism of desipramine-evoked xerostomia. | en |
dc.description.sponsorship | This work was supported by a Korea Research Foundation
Grant funded by the Korean Government (MOEHRD) (RO8- 2004-205-102310) and by Seoul National University. | en |
dc.language.iso | en | en |
dc.publisher | American and International Associations for Dental | en |
dc.subject | desipramine | en |
dc.subject | xerostomia | en |
dc.subject | intracellular pH | en |
dc.subject | Na+/H+ exchange | en |
dc.subject | secretion | en |
dc.title | Desipramine inhibits Na+/H+ exchange in human submandibular cells | en |
dc.type | Article | en |
dc.identifier.doi | 10.1177/154405910608500912 | - |
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