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Glutamate-induced Cobalt Uptake Elicited by Kainate Receptors in RatTaste Bud Cells
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Chung, Ki-Myung | - |
dc.contributor.author | Lee, Seung-Pyo | - |
dc.contributor.author | Lee, Sang-Bok | - |
dc.contributor.author | Heur, Ryang | - |
dc.contributor.author | Cho, Young-Kyung | - |
dc.contributor.author | Lee, Cil-Han | - |
dc.contributor.author | Jung, Hye-Young | - |
dc.contributor.author | Chung, Se-Hwan | - |
dc.contributor.author | Kim, Kyung-Nyun | - |
dc.date.accessioned | 2010-07-12T06:11:18Z | - |
dc.date.available | 2010-07-12T06:11:18Z | - |
dc.date.issued | 2005 | - |
dc.identifier.citation | CHEMICAL SENSES 30, 137-143 | en |
dc.identifier.issn | 0379-864X | - |
dc.identifier.uri | https://hdl.handle.net/10371/68601 | - |
dc.description.abstract | Glutamate-induced cobalt uptake reveals non-N-methyl-D-aspartate (non-NMDA) glutamate receptors (GluRs) in rat taste bud cells. However, it is not known which type of non-NMDA glutamate receptors is involved. We used a cobalt staining technique combined with pharmacological tests for kainate or -amino-3-hydroxy-5-methyl-isoxazole-propionic acid (AMPA) receptors and/or immunohistochemistry against subunits of GluRs to examine the presence of non-NMDA receptors in rat foliate tastebud cells. Cobalt uptake into taste cells was elicited by treating taste buds with glutamate, kainate or SYM 2081, a kainate receptor agonist. Treating taste buds with AMPA or fluorowillardiine did not stimulate significant cobalt uptake. Moreover, 6-cyano-7-nitro-quinoxaline-2, 3-dione significantly reduced cobalt staining elicited by glutamate or kainate receptor agonists, but SYM 2206, an AMPA receptor antagonist, did not. Immunohistochemistry against subunits of GluRs reveals GluR6 and KA1-like immunoreactivity. Moreover, most glutamate-induced cobalt-stained cells showed GluR6 and KA1-like immunoreactivity. These results suggest that glutamate-induced cobalt uptake in taste cells occurs mainly via kainate type GluRs. | en |
dc.description.sponsorship | This work was supported by grant No.
R05-2002-000-00395-0 from the Basic Research Program of the Korea Science & Engineering Foundation. | en |
dc.language.iso | en | en |
dc.publisher | Oxford University Press | en |
dc.subject | AMPA | en |
dc.subject | cobalt staining | en |
dc.subject | foliate papilla | en |
dc.subject | glutamate receptors | en |
dc.subject | kainate | en |
dc.subject | taste bud | en |
dc.title | Glutamate-induced Cobalt Uptake Elicited by Kainate Receptors in RatTaste Bud Cells | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 이승표 | - |
dc.contributor.AlternativeAuthor | 정기명 | - |
dc.contributor.AlternativeAuthor | 이상복 | - |
dc.contributor.AlternativeAuthor | 조영경 | - |
dc.contributor.AlternativeAuthor | 이칠한 | - |
dc.contributor.AlternativeAuthor | 정혜영 | - |
dc.contributor.AlternativeAuthor | 정세환 | - |
dc.contributor.AlternativeAuthor | 김경년 | - |
dc.identifier.doi | 10.1093/chemse/bji009 | - |
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