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Inhibitory action of bisphosphonates on bone resorption does not involve the regulation of RANKL and OPG expression

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dc.contributor.authorKim, Gwan-Shik-
dc.contributor.authorKim, Young Hee-
dc.contributor.authorBaek, Jeong-Hwa-
dc.date.accessioned2010-07-12T06:35:33Z-
dc.date.available2010-07-12T06:35:33Z-
dc.date.issued2002-05-
dc.identifier.citationExperimental and Molecular Medicine 2002;34:145-151en
dc.identifier.issn1226-3613-
dc.identifier.urihttp://hdl.handle.net/10371/68604-
dc.description.abstractThe mechanism of inhibitory action of bisphosphonates on bone resorption is not fully elucidated. Osteoclast formation and activity are regulated by osteoblast-derived factors such as the osteoclast differentiating factor, receptor activator of NF-kappaB ligand (RANKL) and the inhibitor, osteoprotegerin (OPG). To investigate in vitro effects of bisphosphonates on mouse osteoblastic cells, we examined the expression levels of RANKL and OPG in the cells treated with alendronate or pamidronate (10(-8)~10(-5) M) alone, or combined with 10 nM of 1,25-(OH)(2)VitD(3) for 24 or 48 h. Various concentrations of alendronate and pamidronate did not change the mRNA expression of RANKL and OPG consistently irrespective of 1,25-(OH)(2)VitD(3) presence. When added into cocultures of mouse osteoblastic cells and bone marrow cells, both alendronate and pamidronate inhibited osteoclast formation and bone resorption but failed to alter the RANKL and OPG mRNA expression. These results indicate that the inhibition of bone resorption by bisphosphonates is not mediated by the regulation of RANKL and OPG expression.en
dc.language.isoenen
dc.publisherKorean Society of Medical Biochemistryen
dc.subjectRANKLen
dc.subjectOPGen
dc.subjectalendronateen
dc.subjectpamidronateen
dc.subjectosteoclastogenesisen
dc.titleInhibitory action of bisphosphonates on bone resorption does not involve the regulation of RANKL and OPG expressionen
dc.typeArticleen
dc.contributor.AlternativeAuthor김관식-
dc.contributor.AlternativeAuthor김영희-
dc.contributor.AlternativeAuthor백정화-
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College of Dentistry/School of Dentistry (치과대학/치의학대학원)Dept. of Dentistry (치의학과)Journal Papers (저널논문_치의학과)
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